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Titolo:
Ex vivo bactericidal activity against group C Neisseria meningitidis in seronegative subjects
Autore:
Gomez-Lus, ML; Aguilar, L; Vazquez, J; Gimenez, MJ; Ruiz, G; Berron, S; Fuentes, F; Prieto, J;
Indirizzi:
Univ Complutense Madrid, Sch Med, Dept Microbiol, ES-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain ES-28040 ol, ES-28040 Madrid, Spain SmithKline Beecham Pharmaceut, Dept Med, ES-28034 Madrid, Spain SmithKlineBeecham Pharmaceut Madrid Spain ES-28034 -28034 Madrid, Spain Carlos III Hlth Inst, Natl Microbiol Ctr, ES-28220 Madrid, Spain Carlos III Hlth Inst Madrid Spain ES-28220 l Ctr, ES-28220 Madrid, Spain
Titolo Testata:
INFECTION
fascicolo: 5, volume: 28, anno: 2000,
pagine: 305 - 308
SICI:
0300-8126(200009)28:5<305:EVBAAG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE VESICLE VACCINE; ANTIBODY-RESPONSE; MENINGOCOCCI; IMMUNIZATION; NEUTROPHILS; SERA; US;
Keywords:
ex vivo bactericidal activity; group C Neisseria meningitidis; seronegative; opsonophagocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, J Univ Complutense Madrid, Sch Med, Dept Microbiol, Avda Complutense S-N, ES-28040 Madrid, Spain Univ Complutense Madrid Avda Complutense S-NMadrid Spain ES-28040
Citazione:
M.L. Gomez-Lus et al., "Ex vivo bactericidal activity against group C Neisseria meningitidis in seronegative subjects", INFECTION, 28(5), 2000, pp. 305-308

Abstract

Background: To determine the anti-meningococcal C immunological activity by adding functional tests (opsonophagocytosis) to the classical serology techniques. Subjects and Methods: 42 adult volunteers were screened using serological methods (determination of total and bactericidal antibodies). Seronegative subjects were tested by opsonophagocytosis,Results: 24 subjects (57%) showed serological evidence of previous contactwith Neisseria meningitidis group C antigens: 19 subjects had both total and bactericidal antibodies, two subjects had only total antibodies and three subjects had only bactericidal antibodies. Of the 18 seronegative subjects, five showed ex vivo activity in killing curves with or without polymorphonuclear cells: two subjects exhibited only complement-mediated bactericidal activity, one subject only opsonophagocytosis, and two subjects exhibitedboth activities. Conclusion: The addition of functional tests to the classical serological determination increases the evidence of previous contact with N. meningitidis antigens by 12%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:33:28