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Titolo:
Second generation amplicor-HCV monitor assay: clinical features and predictors of the response to interferon
Autore:
Ide, T; Kumashiro, R; Toyoda, N; Matsuyama, K; Miura, T; Sata, M;
Indirizzi:
Kurume Univ, Sch Med, Dept Internal Med 2, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Kurume Univ, Sch Med, Clin Lab, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 18, anno: 2000,
pagine: 230 - 238
SICI:
1386-6346(200011)18:3<230:SGAMAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; POLYMERASE CHAIN-REACTION; NON-B HEPATITIS; CHRONIC NON-A; ALPHA-INTERFERON; CONTROLLED TRIAL; RNA; GENOTYPES; THERAPY; SERUM;
Keywords:
amplicor-HCV monitor assay (version 2.0); chronic hepatitis C; interferon treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ide, T Kurume Univ, Sch Med, Dept Internal Med 2, 67 Asahi Machi, Kurume, Fukuoka8300011, Japan Kurume Univ 67 Asahi Machi Kurume Fukuoka Japan 8300011 0011, Japan
Citazione:
T. Ide et al., "Second generation amplicor-HCV monitor assay: clinical features and predictors of the response to interferon", HEPATOL RES, 18(3), 2000, pp. 230-238

Abstract

The aims of this study were to compare the amplicor-HCV monitor assay versions 1.0 and 2.0, and to investigate the clinical usefulness of this assay in patients with chronic hepatitis C. We retrospectively analyzed 154 patients, and 133 of these patients received interferon therapy. Sixty-nine patients were complete responders (CR), and 64 were non-responders. Serum HCV RNA levels of version 1.0 and version 2.0 and HCV genotypes were determined in all patients. There was a good correlation between versions 1.0 and 2.0 in both genotype Ib and 2a, 2b (r = 0.907 and 0.726, respectively). In genotype Ib, the mean HCV RNA level obtained by version 1.0 was 384 +/- 547 kcopies/ml and that obtained by version 2.0 was 488 +/- 825 kI.U./ml. In genotype 2a/2b, the mean level obtained by version 1.0 was 170 +/- 369 kcopies/ml and that obtained by version 2.0 was 340+/-402 kI.U./ml. Discriminant analysis revealed that the discriminating points of IFN response were 168 kcopies/ml (genotype Ib, version 1.0), 106 kcopies/ml (genotype 2a and 2b, version 1.0), 102 kI.U./ml (genotype Ib, version 2.0), and 277 kI.U./ml (genotype 2a and 2b, version 2.0. When the patients were stratified according to the discriminating points, the CR rate below the discriminating points were 73.8 and 86.2% in versions 1.0 and 2.0, respectively, in genotype Ib, and the rates were 73.2 and 82.3% in genotype 2a/2b. In addition, receiver-operating characteristic analysis revealed that version 2.0 had significantly better discriminative ability in patients with genotype 1b. We conclude that the second version of the amplicor-HCV monitor assay measures HCV RNA levels with the same precision as version 1.0 and is more useful for the prediction of interferon response than version 1.0. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:42:14