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Titolo:
In vivo subcellular elemental dynamics in liver graft: With special reference to effect of non-selective endothelin receptor antagonist, TAK-044, on the graft injury
Autore:
Takaya, Y; Yamanaka, N; Oriyama, T; Furukawa, K; Tanaka, T; Nakagaki, I; Sasaki, S; Hori, S; Okamoto, E;
Indirizzi:
Hyogo Coll Med, Dept Surg 1, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Coll Med, Dept Physiol 1, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 18, anno: 2000,
pagine: 171 - 183
SICI:
1386-6346(200011)18:3<171:IVSEDI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY-MICROANALYSIS; ISCHEMIA-REPERFUSION INJURY; IN-VIVO; CALCIUM; CELLS; RATS; TRANSPLANTATION; PATHOGENESIS; CRYOSECTIONS; INVOLVEMENT;
Keywords:
liver transplantation; subcellular element; endothelin receptor antagonist; ischemia reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yamanaka, N Hyogo Coll Med, Dept Surg 1, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501,Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
Y. Takaya et al., "In vivo subcellular elemental dynamics in liver graft: With special reference to effect of non-selective endothelin receptor antagonist, TAK-044, on the graft injury", HEPATOL RES, 18(3), 2000, pp. 171-183

Abstract

Background: No data are available concerning the in vivo subcellular dynamics of elements in liver grafts and the effect of endothelin receptor antagonist, TAK-044, against graft injury. Methods: Liver transplantation was performed in porcine under active veno-venous bypass. The grafts stored in chilled preservation solution were recirculated following reflush with lactated Ringer's solution with or without TAK-044 (10 mg/kg). Cold and warm ischemic times of the grafts were comparable between the two groups. Elements (Na, K. Cl, Ca, P and S) were measured in three fractions of cytoplasm, mitochondria and nucleus by electron probe X-ray microanalysis for the graft biopsy specimens obtained at various time from donor laparotomy to 1 week after liver grafting. Liver functions also were compared between the two groups. Results: In both groups, concentration of each element changed in parallel among the three subcellular fractions and their changes were less markedin the nucleus. In the control group, there were significant increases in cytoplasmic Na and Cl after portal reperfusion and ill cytoplasmic and mitochondrial Ca after hepatic artery reperfusion. These were accompanied by K and mitochondrial S decreases without; a statistical significance. In the TAK group, such postreperfusion elemental alterations were significantly suppressed and early deterioration of the liver functions was alleviated, as compared with the control group. Conclusion: A supplemental use of TAK-044 in a rinse solution before reflush contributed to stability of subcellular elements after reperfusion and better preservation of early graft function. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:06:39