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Titolo:
Modelling convergent input onto interaural-delay-sensitive inferior colliculus neurones
Autore:
Shackleton, TM; McAlpine, D; Palmer, AR;
Indirizzi:
Univ Nottingham, MRC, Inst Hearing Res, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Univ London Univ Coll, Dept Physiol, London WC1E 6BT, England Univ London Univ Coll London England WC1E 6BT , London WC1E 6BT, England
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 149, anno: 2000,
pagine: 199 - 215
SICI:
0378-5955(200011)149:1-2<199:MCIOII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-FREQUENCY NEURONS; SUPERIOR OLIVARY COMPLEX; AUDITORY-NERVE FIBERS; CENTRAL NUCLEUS; BINAURAL INTERACTION; BRAIN-STEM; RESPONSE PROPERTIES; CHANGING FREQUENCY; LATERAL LEMNISCUS; COCHLEAR NUCLEUS;
Keywords:
interaural time difference; inferior colliculus; binaural; coincidence detection; Jeffress model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Shackleton, TM Univ Nottingham, MRC, Inst Hearing Res, Univ Pk, NottinghamNG7 2RD, England Univ Nottingham Univ Pk Nottingham England NG7 2RD England
Citazione:
T.M. Shackleton et al., "Modelling convergent input onto interaural-delay-sensitive inferior colliculus neurones", HEARING RES, 149(1-2), 2000, pp. 199-215

Abstract

Convergent input from cells in the medial superior olive (MSO) and lateralsuperior olive (LSO) onto a single inferior colliculus (IC) cell explains many findings that are not compatible with a simple coincidence detector mechanism. Here this explanation is tested using a physiologically accurate computer model of the binaural pathway in which the input to the IC cell is either from two MSO cells or a MSO and a LSO cell. Auditory nerve (AN) spike trains are formed by a stochastic hair cell model following a basilar membrane simulation using a gammatone filter. In subsequent cells input spikescause post-synaptic potentials (PSPs) which are summed causing the cell tofire when the stun crosses a threshold. The individual cells are matched to the physiology by varying the number of inputs, the magnitude and duration of the PSPs and the firing threshold. Non-linear best-phase-versus-frequency functions arise if the two IC inputs have different best frequencies and different characteristic delays. One input can be selectively suppressed by turning on an additional tone at the worst phase of that input. Non-zerocharacteristic phases arise if the characteristic frequencies of the AN fibres feeding into a single superior olive cell are mismatched. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:33:16