Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estrogen-induced remodeling of hypothalamic neural circuitry
Autore:
Flanagan-Cato, LM;
Indirizzi:
Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Psychol, Philadelphia, PA 19104 USA Univ Penn, Inst Neurol Sci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 eurol Sci, Philadelphia, PA 19104 USA
Titolo Testata:
FRONTIERS IN NEUROENDOCRINOLOGY
fascicolo: 4, volume: 21, anno: 2000,
pagine: 309 - 329
SICI:
0091-3022(200010)21:4<309:EROHNC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE RAT-BRAIN; RECEPTOR-IMMUNOREACTIVE CELLS; NUCLEUS VENTROMEDIALIS HYPOTHALAMI; DENDRITIC SPINE DENSITY; PREOPTIC-AREA PROTEINS; CENTRAL-NERVOUS-SYSTEM; GUINEA-PIG BRAIN; MESSENGER-RNA; SEXUAL-BEHAVIOR; INSITU HYBRIDIZATION;
Keywords:
estrogen; dendritic spines; lordosis; pseudorabies virus; ventromedial hypothalamus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Flanagan-Cato, LM Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA Univ Penn 3815 Walnut St Philadelphia PA USA 19104 4 USA
Citazione:
L.M. Flanagan-Cato, "Estrogen-induced remodeling of hypothalamic neural circuitry", FRONT NEURO, 21(4), 2000, pp. 309-329

Abstract

For decades, sexual behavior has been a valuable model system for behavioral neuroscientists studying the neural basis of motivated behaviors. One striking example of a change in motivation is the binary switch in sexual receptivity that occurs during the estrous cycle in female rats. Investigations of the neural basis of this change in behavior have fundamentally advanced our understanding of both behaviorally relevant neural pathways and basicmechanisms of steroid action in the brain. These advances have made this behavioral model system a staple of neuroendocrinology. A challenge that remains before us, given our current understanding of the circuitry and chemistry, is to develop a coherent model of how neural plasticity in the hypothalamus contributes to the dependence of this behavior on motivational state. This review will focus on the ventromedial nucleus of the hypothalamus, especially its ventrolateral subdivision. First, the anatomical, neurochemical, and functional aspects of the macro- and microcircuitry of this brain region will be discussed, followed by a discussion of the likely mechanisms of estrogen action within the ventrolateral VMH. Then, the evidence for estrogen-induced neural plasticity will be considered, including a comparison with the effects of estrogen on synaptic organization in other brain regions. Finally, a working model of neural plasticity within the ventrolateral VMH microcircuitry will be presented as a starting point for future experiments to verify or, more likely, revise and expand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:47:30