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Titolo:
Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells
Autore:
Bhaumik, S; Jyothi, MD; Khar, A;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 483, anno: 2000,
pagine: 78 - 82
SICI:
0014-5793(20001013)483:1<78:DMONOP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; TUMOR-NECROSIS-FACTOR; AK-5 TUMOR; ANTIINFLAMMATORY AGENT; APOPTOSIS; HISTIOCYTOMA; INDUCTION; CANCER; LINES; INTERLEUKIN-12;
Keywords:
nitric oxide; inducible nitric oxide synthase; macrophage; NK cell; tumor regression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
S. Bhaumik et al., "Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells", FEBS LETTER, 483(1), 2000, pp. 78-82

Abstract

Curcumin, the yellow pigment from Curcuma longa, has been shown to possesstumoricidal activity. We have earlier reported the induction of apoptosis in AK-5, rat histiocytic cells by curcumin leading to the inhibition of tumor growth in vivo. In this study me have observed differential activation status in host macrophages and NK cells induced by curcumin during the spontaneous regression of subcutaneously transplanted AK-5 tumors. Closer scrutiny of the cytokine profile and nitric oxide (NO) production by immune cellsshowed an initial downregulation of Th1 cytokine response and WO production by macrophages, and their upregulation in NK cells, which picked-up upon prolonged treatment with curcumin, culminating in a stronger tumoricidal effect. These studies suggest that the host macrophages and NK cells play an important modulatory role in the remission of AK-5 tumor. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:50:36