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Titolo:
Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis
Autore:
Yoshioka, T; Nakajima, A; Akiba, H; Ishiwata, T; Asano, G; Yoshino, S; Yagita, H; Okumura, K;
Indirizzi:
Nippon Med Sch, Dept Joint Dis & Rheumatism, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 Joint Dis & Rheumatism, Tokyo 113, Japan Juntendo Univ, Sch Med, Dept Immunol, Tokyo, Japan Juntendo Univ Tokyo Japan ndo Univ, Sch Med, Dept Immunol, Tokyo, Japan Japan Sci & Technol Corp, CREST, Tokyo, Japan Japan Sci & Technol Corp Tokyo Japan Technol Corp, CREST, Tokyo, Japan Nippon Med Sch, Dept Pathol, Tokyo 113, Japan Nippon Med Sch Tokyo Japan113 on Med Sch, Dept Pathol, Tokyo 113, Japan
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 30, anno: 2000,
pagine: 2815 - 2823
SICI:
0014-2980(200010)30:10<2815:COOLIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN-INDUCED ARTHRITIS; T-CELL ACTIVATION; OX40 LIGAND; COSTIMULATORY MOLECULE; AUTOIMMUNE-DISEASE; SYNOVIAL-FLUID; LYMPHOCYTES-T; IN-VITRO; B-CELLS; RECEPTOR;
Keywords:
co-stimulation; OX40-OX40L; rheumatoid arthritis; collagen-induced arthritis; Th1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajima, A 1180 Reed Ave 3, Sunnyvale, CA 94086 USA 1180 Reed Ave 3 Sunnyvale CA USA 94086 unnyvale, CA 94086 USA
Citazione:
T. Yoshioka et al., "Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis", EUR J IMMUN, 30(10), 2000, pp. 2815-2823

Abstract

OX40 ligand (OX40L) and OX40 (CD134) are a pair of cell surface molecules belonging to the TNF/TNF receptor family. Interaction of OX40L with its receptor OX40 is thought to be important in T cell activation through T cell/antigen-presenting cell interaction. However, involvement of these moleculesin the pathogenesis of rheumatoid arthritis (RA) remains unclear. To explore the contribution of OX40/OX40L interaction to the pathogenesis of RA in vivo, we evaluated the effect of a neutralizing anti-OX40L monoclonal antibody (mAb) on the development of collagen-induced arthritis (CIA) in DBA/1 mice as an animal model for RA. Administration of anti-OX40L mAb into type II collagen (CII) -immunized DBA/1 mice dramatically ameliorated the diseaseseverity. In vivo treatment with anti-OX40L mAb did not inhibit the expansion of CII-reactive T cells, but suppressed IFN-gamma and anti-CII IgG2a production. Therefore, OX40/OX40L interaction appears to play a critical rolein the development of CIA by enhancing Th1-type autoimmune response. In addition, T lymphocytes in synovial fluid and synovial tissue from RA patients expressed OX40, while OX40L was expressed on sublining cells in synovial tissue. These results indicate that OX40/OX40L interaction may play a critical role in the development of RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:11