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Titolo:
Selective activation of the hypothalamic vasopressinelgic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent onglucocorticoids
Autore:
Muller, MB; Landgraf, R; Preil, J; Sillaber, I; Kresse, AE; Keck, ME; Zimmermann, S; Holsboer, F; Wurst, W;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany GSF, Res Ctr, Inst Mammalian Genet, D-85764 Munich, Germany GSF Munich Germany D-85764 Inst Mammalian Genet, D-85764 Munich, Germany Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Biol, Stockholm, Sweden Karolinska Inst Stockholm Sweden ophys, Div Mol Biol, Stockholm, Sweden
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 11, volume: 141, anno: 2000,
pagine: 4262 - 4269
SICI:
0013-7227(200011)141:11<4262:SAOTHV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED STRESS-RESPONSE; ADRENOCORTICOTROPIN SECRETION; ANTISENSE OLIGODEOXYNUCLEOTIDE; PARAVENTRICULAR NUCLEUS; ARGININE VASOPRESSIN; EMOTIONAL-STRESS; CHRONIC INFUSION; REDUCED ANXIETY; RAT; PITUITARY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Wurst, W Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2-10 Munich Germany D-80804
Citazione:
M.B. Muller et al., "Selective activation of the hypothalamic vasopressinelgic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent onglucocorticoids", ENDOCRINOL, 141(11), 2000, pp. 4262-4269

Abstract

Deficiency of CRH receptor 1 (CRHR1) severely impairs the stress response of the hypothalamic-pituitary-adrenocortical (HPA) system and reduces anxiety-related behavior in mice. Intriguingly, in mice deficient for the CRHR1 (Crhr1(-/-)), basal plasma levels of ACTH are normal, suggesting the presence of compensatory mechanisms for pituitary ACTH secretion. We therefore studied the impact of the hypothalamic neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) on HPA system regulation in homozygous and heterozygous Crhr1 mutants under basal and different stress conditions. Basal plasma AVP concentrations were significantly elevated in Crhr1(-/-) mice. AW messenger RNA expression was increased in the paraventricular nucleus of Crhr1(-/-) mutants together with a marked increase in AW-like immunoreactivity in the median eminence. Administration of an AVP V-1-receptor antagonist significantly decreased basal plasma ACTH levels in mutant mice. After continuous treatment with corticosterone, plasma AVP levels in homozygous Crhr1(-/-)mice were indistinguishable from those in wild-type littermates, thus providing evidence that glucocorticoid deficiency is the major driving force behind compensatory activation of the vasopressinergic system in Crhr1(-/-) mice. Neither plasma OXT levels under several different conditions nor OXT messenger RNA expression in the paraventricular nucleus were different between the genotypes. Taken together, our data reveal a selective compensatory activation of the hypothalamic vasopressinergic, but not the oxytocinergic system, to maintain basal ACTH secretion and HPA system activity in Crhr1(-/-) mutants.

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Documento generato il 09/07/20 alle ore 00:59:05