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Titolo:
GENOMIC STRUCTURE OF THE BOVINE MB-1 GENE ENCODING THE IG-ALPHA SUBUNIT OF THE B-CELL ANTIGEN RECEPTOR COMPLEX
Autore:
YOUN HY; CHO KW; NISHIMURA Y; GOITSUKA R; WATARI T; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU,1-1-1 YAYOI TOKYO 113 JAPAN UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU TOKYO 113 JAPAN SEOUL NATL UNIV,COLL VET MED,VET TEACHING HOSP,DEPT VET INTERNAL MED,KWANAK KU SEOUL 151742 SOUTH KOREA SCI UNIV TOKYO,RES INST BIOL SCI,DIV MOL BIOL NODA CHIBA 278 JAPAN
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3-4, volume: 56, anno: 1997,
pagine: 247 - 257
SICI:
0165-2427(1997)56:3-4<247:GSOTBM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTORS; PROMOTER SEQUENCES; BINDING SITES; PRE-B; IMMUNOGLOBULIN; EXPRESSION; CLONING; PROTEIN; B29; ACTIVATION;
Keywords:
B-LYMPHOCYTE; BOVINE; GENOMIC MB-1 GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
H.Y. Youn et al., "GENOMIC STRUCTURE OF THE BOVINE MB-1 GENE ENCODING THE IG-ALPHA SUBUNIT OF THE B-CELL ANTIGEN RECEPTOR COMPLEX", Veterinary immunology and immunopathology, 56(3-4), 1997, pp. 247-257

Abstract

The B cell antigen receptor (BCR) comprises surface immunoglobulin and disulfide-bonded heterodimer of Ig-alpha and Ig-beta chains, which are the products of the mb-1 and B29 genes, respectively. In this study, we describe the isolation and analysis of a 6.2-kb genomic DNA clonecontaining bovine mb-1 gene encoding Ig-alpha. Sequence data revealedthat the bovine mb-1 gene is composed of five exons and four introns,and that its overall structure is very similar to those of murine andhuman genes. The 5' upstream region of the bovine mb-1 gene containedpotential protein binding motifs of transcription factors including EBF, Spl, NF-kappa B, MUF/Ets-1 and AP-2, As with the murine and human mb-1 genes, the 5' region of the bovine mb-1 gene lacked a TATA box. The present study will be useful for understanding the regulated expression of the bovine mb-1 gene at different stages of development and activation as well as in bovine leukemia virus infection. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:29:44