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Titolo:
Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
Autore:
Venkataramanan, R; Ramachandran, V; Komoroski, BJ; Zhang, SM; Schiff, PL; Strom, SC;
Indirizzi:
Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 eut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pathol, Pittsburgh, PA 15261 USA
Titolo Testata:
DRUG METABOLISM AND DISPOSITION
fascicolo: 11, volume: 28, anno: 2000,
pagine: 1270 - 1273
SICI:
0090-9556(200011)28:11<1270:MTAHSD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LIPID-PEROXIDATION; LIVER-DAMAGE; SILYMARIN; CYTOCHROME-P-450; INTOXICATION; ANTIOXIDANT; PREVENTION; PROTECTION; SILIBININ; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Venkataramanan, R Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, 718 Salk Hall, Pittsburgh, PA 15261 USA Univ Pittsburgh 718 Salk Hall Pittsburgh PA USA 15261 SA
Citazione:
R. Venkataramanan et al., "Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures", DRUG META D, 28(11), 2000, pp. 1270-1273

Abstract

Milk thistle extract is one of the most commonly used nontraditional therapies, particularly in Germany. Milk thistle is known to contain a number offlavonolignans. We evaluated the effect of silymarin, on the activity of various hepatic drug-metabolizing enzymes in human hepatocyte cultures. Treatment with silymarin (0.1 and 0.25 mM) significantly reduced the activity of CYP3A4 enzyme (by 50 and 100%, respectively) as determined by the formation of 6-beta-hydroxy testosterone and the activity of uridine diphosphoglucuronosyl transferase (UGT1A6/9) (by 65 and 100%, respectively) as measured by the formation of 4-methylumbelliferone glucuronide. Silymarin (0.5 mM) also significantly decreased mitochondrial respiration as determined by MTT reduction in human hepatocytes. These observations point to the potential of silymarin to impair hepatic metabolism of certain coadministered drugs inhumans. Indiscriminate use of herbal products may lead to altered pharmacokinetics of certain drugs and may result in increased toxicity of certain drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:27:08