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Titolo:
PYY regulates pancreatic exocrine secretion through multiple receptors in the awake rat
Autore:
Guarita, DR; Deng, X; Huh, YB; Wood, PG; Reeve, JR; Whitcomb, DC;
Indirizzi:
Univ Pittsburgh, Dept Med, Div Gastroenterol & Hepatol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Hepatol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Physiol, Pittsburgh, PA 15261 USA Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA Univ Calif LosAngeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA VA Greater Los Angeles Hlth Care Syst, CURE, Digest Dis Res Ctr, Los Angeles, CA USA VA Greater Los Angeles Hlth Care Syst Los Angeles CA USA Angeles, CA USA Pittsburgh Vet Affairs Med Ctr, Pittsburgh, PA USA Pittsburgh Vet Affairs Med Ctr Pittsburgh PA USA Ctr, Pittsburgh, PA USA
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 9, volume: 45, anno: 2000,
pagine: 1696 - 1702
SICI:
0163-2116(200009)45:9<1696:PRPEST>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL VAGAL COMPLEX; PEPTIDE YY PYY; NEUROPEPTIDE-Y; RELEASE; DOG; RADIOIMMUNOASSAY; CHOLECYSTOKININ; LOCALIZATION; STIMULATION; INHIBITION;
Keywords:
gut-brain axis; brain stem; dorsal vagal complex; Y receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Whitcomb, DC Univ Pittsburgh, Dept Med, Div Gastroenterol & Hepatol, 571 Scaife Hall,3550 Terrace St, Pittsburgh, PA 15261 USA Univ Pittsburgh 571 Scaife Hall,3550 Terrace St Pittsburgh PA USA 15261
Citazione:
D.R. Guarita et al., "PYY regulates pancreatic exocrine secretion through multiple receptors in the awake rat", DIG DIS SCI, 45(9), 2000, pp. 1696-1702

Abstract

Peptide YY (PYY) is one of several regulatory peptides reported to modulate pancreatic secretion. PYY circulates in two forms, PYY1-36 and PYY3-36 and binds to multiple receptor subtypes. We sought to determine if PYY1-36 orPYY3-36 regulates neurally mediated pancreatic secretion through the Y1, Y2, and/or Y5 receptor subtypes. Experiments were conducted in awake, surgically recovered rats. In order to determine the effects of the PYYs on basalpancreatic secretion, either PYY1-36, [pro(34)] PYY1-36 (a Y1/Y5 agonist),or PYY3-36 (a Y2/Y5 agonist) were infused for 40 min at doses of 0, 12.5, 25, or 50 pmol/kg/hr while measuring pancreatic juice volume and protein. PYY1-36 increased pancreatic protein secretion at 25 and 50 pmol/kg/hr (P < 0.05) in a dose-dependent manner (P < 0.001, R-2 = 0.990). The Y2/Y5 receptor agonist PYY3-36 significantly inhibited pancreatic juice volume and protein at 12.5 and 25 pmol/kg/hr, but stimulated protein secretion at higher doses (P < 0.001, R-2 = 0.995). The Y1/Y5 agonist,[Pro(34)] PYY1-36, had no significant effect on basal pancreatic exocrine secretion. Therefore, PYY1-36 PYY3-36 and [Pro(34)] PYY1-36 produced different, dose-dependent changeson basal pancreatic exocrine secretion. Inhibition of pancreatic secretionby circulating PYY1-36 and PYY3-36 are primarily mediated by the Y2 receptor. Since [Pro(34)] PYY1-36 did not change pancreatic secretion, it can be concluded that circulating PYY1-36 or PYY3-36 does not modulate pancreatic secretion through the Y1 or Y5 receptors. Since the stimulatory effects of PYY1-36 on pancreatic secretion could not be explained by the actions of PYY3-36 or [Pro(34)] PYY1-36 on Y1 or Y2 receptors, and since PYY1-36 fails to bind to Y3 or Y4 receptors, we also conclude that PYY1-36 may stimulate pancreatic secretion in a dose-dependent mechanism through a PYY receptor subtype different from Y1, Y2, Y3, Y4 or Y5.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:45:51