Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of long-term dietary protein intake on glucose metabolism in humans
Autore:
Linn, T; Santosa, B; Gronemeyer, D; Aygen, S; Scholz, N; Busch, M; Bretzel, RG;
Indirizzi:
Univ Giessen, Clin Res Unit, Med Clin 3, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 ed Clin 3, D-35392 Giessen, Germany Univ Witten Herdecke, Dept Radiol & MicroTherapy, Witten, Germany Univ Witten Herdecke Witten Germany iol & MicroTherapy, Witten, Germany Univ Witten Herdecke, Inst Clin Chem, Witten, Germany Univ Witten Herdecke Witten Germany ke, Inst Clin Chem, Witten, Germany Med Clin 3, Div Diabet & Metab, Giessen, Germany Med Clin 3 Giessen Germany Clin 3, Div Diabet & Metab, Giessen, Germany
Titolo Testata:
DIABETOLOGIA
fascicolo: 10, volume: 43, anno: 2000,
pagine: 1257 - 1265
SICI:
0012-186X(200010)43:10<1257:EOLDPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; DEPENDENT DIABETES-MELLITUS; CHRONIC-RENAL-FAILURE; AMINO-ACID OXIDATION; GROWTH-FACTOR-I; INSULIN-SECRETION; HEPATIC GLYCOGENOLYSIS; PLASMA-GLUCOSE; BETA-CELLS; GLUCONEOGENESIS;
Keywords:
endogeneous insulin; hepatic glucose production; high protein diet; normal protein diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Linn, T Univ Giessen, Clin Res Unit, Med Clin 3, Rodthohl 6, D-35392 Giessen, Germany Univ Giessen Rodthohl 6 Giessen Germany D-35392 Giessen, Germany
Citazione:
T. Linn et al., "Effect of long-term dietary protein intake on glucose metabolism in humans", DIABETOLOG, 43(10), 2000, pp. 1257-1265

Abstract

Aims/hypothesis. A meal rich in protein stimulates insulin secretion. Long-term effects of dietary protein on insulin release and glucose metabolism are, however, still not known. Our study focussed on the effect of different protein intake on pancreatic insulin secretion capacity, glycogen turnover and gluconeogenesis. Methods. Subjects with constant (6 months) dietary protein of 1.87+/-0.26 g.kg(-1).day(-1) (1.25-2.41) named high protein group and with 0.74+/-0.08 (0.57-0.80), normal protein group, were identified by a food questionnaire and were matched (n = 9) according to sex, age and calorie intake. They underwent an intravenous glucose tolerance test and a euglycaemic hyperinsulinaemic clamp with infusion of [6,6-H-2(2)]-glucose combined with indirect calorimetry. To estimate net gluconeogenesis the usual diet was enriched by deuterated water or U-[C-13(6)]-glucose and breath and plasma were sampled. Results. Glucose-stimulated insulin secretion was increased in the high protein group (516 +/- 45 pmol/l vs 305 +/- 32, p = 0.012) due to reduced glucose threshold of the endocrine beta cells (4.2+/-0.5 mmol/l vs 4.9 +/- 0.3, p = 0.031). Endogeneous glucose output was increased by 12 % (p = 0.009) at 40 pmol/l plasma insulin in the high protein group, but not at higher insulin concentration whereas overall glucose disposal was reduced. Fasting plasma glucagon was 34% increased in the high protein group (p = 0.038). Fractional gluconeogenesis was increased by 40 % in subjects receiving a high protein diet as determined by both methods. Conclusion/interpretation. High protein diet is accompanied by increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover and stimulation of gluconeogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:38:01