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Titolo:
Gastroduodenal mucosal defense
Autore:
Holzer, P;
Indirizzi:
Graz Univ, Dept Expt & Clin Pharmacol, A-8010 Graz, Austria Graz Univ Graz Austria A-8010 xpt & Clin Pharmacol, A-8010 Graz, Austria
Titolo Testata:
CURRENT OPINION IN GASTROENTEROLOGY
fascicolo: 6, volume: 16, anno: 2000,
pagine: 469 - 478
SICI:
0267-1379(200011)16:6<469:GMD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; EPIDERMAL GROWTH-FACTOR; RAT GASTRIC-MUCOSA; HELICOBACTER-PYLORI LIPOPOLYSACCHARIDE; DUODENAL BICARBONATE SECRETION; PORTAL HYPERTENSIVE RATS; MESSENGER-RNA EXPRESSION; GENE-RELATED PEPTIDE; SENSORY NERVES; BLOOD-FLOW;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Holzer, P Graz Univ, Dept Expt & Clin Pharmacol, Univ Pl 4, A-8010 Graz, Austria Graz Univ Univ Pl 4 Graz Austria A-8010 4, A-8010 Graz, Austria
Citazione:
P. Holzer, "Gastroduodenal mucosal defense", CURR OPIN G, 16(6), 2000, pp. 469-478

Abstract

The gastroduodenal mucosa is a model system of defense with several structural levels and biologic strategies that are closely interrelated with eachother to cope with the harmful ingredients of ingested food and the potentially deleterious effects of gastric acid and pepsin, Experimental and clinical research carried out during the review period added to the understanding of each component of the multiple mechanisms of gastroduodenal mucosal protection. In the first place, mucosal integrity is defended by the mucus gel barrier, the epithelial cell barrier, and the immune barrier. The properties of these barriers are maintained by adequate regulation of mucus production, bicarbonate secretion, mucosal microcirculation, and motor activity. These regulatory systems are alarmed by nociceptive neurons and the mucosal immune system which includes chemokine-secreting epithelial cells. The ultimate defense system is rapid repair of the injured mucosa under the control of several growth factors. Progressing insight into the network of mucosal defense not only will improve existing therapies of inflammation and ulceration but also will provide new leads for the management of functional diseases in the gastroduodenal region. (C) 2000 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:43:10