Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Adrenal responsiveness to high, low and very low ACTH 1-24 doses in obesity
Autore:
Maccario, M; Grottoli, S; DiVito, L; Rossetto, R; Tassone, F; Ganzaroli, C; Oleandri, SE; Arvat, E; Ghigo, E;
Indirizzi:
Univ Turin, Dept Internal Med, Div Endocrinol & Metab, I-10124 Turin, Italy Univ Turin Turin Italy I-10124 Endocrinol & Metab, I-10124 Turin, Italy
Titolo Testata:
CLINICAL ENDOCRINOLOGY
fascicolo: 4, volume: 53, anno: 2000,
pagine: 437 - 444
SICI:
0300-0664(200010)53:4<437:ARTHLA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; ADRENOCORTICOTROPIN STIMULATION TEST; CORTISOL SECRETION; ABDOMINAL OBESITY; DEHYDROEPIANDROSTERONE-SULFATE; WOMEN; AXIS; INSULIN; MEN; DEXFENFLURAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ghigo, E Molinette Mauriziano Hosp, Div Endocrinol, Corso Dogliotti 14, I-10126 Turin, Italy Molinette Mauriziano Hosp Corso Dogliotti 14 Turin Italy I-10126
Citazione:
M. Maccario et al., "Adrenal responsiveness to high, low and very low ACTH 1-24 doses in obesity", CLIN ENDOCR, 53(4), 2000, pp. 437-444

Abstract

OBJECTIVE To investigate adrenal activity in visceral obesity in which adrenal hyperactivity has been hypothesized. This could reflect hypothalamus-pituitary alterations leading to slight hyperfunction of the adrenal. Primary adrenal hypersensitivity to ACTH drive in obesity has also been suggested. However, it has also been reported that dehydroepiondrosterone (DHEA) levels in obesity are reduced and it has been hypothesized that this could play a role in the increased cardiovascular risk in obese patients. SUBJECTS We have studied seven obese women with visceral adiposity (OB, age: 33.6 +/- 3.3 years, BMI: 33.8 +/- 1.3 kg/m(2), WHR: 0.88 +/- 0.01). The results in OB were compared with those recorded in a group of age-matched normal women (NS, age: 30 +/- 1.3 years, BMI: 19.9 +/- 0.4 kg/m(2), WHR: 0.76 +/- 0.02). We have studied the cortisol (F), aldosterone (A) and DHEA responses to ACTH 1-24 administered at low (LD, 0.5 mu g/m(2)) or very low (VLD, 0.125 mu g/m(2)) dose followed by a second challenge with supramaximal dose (HD, 250mu g). RESULTS Basal F, A and DHEA levels in OB were similar to those in NS. The peak F responses to ACTH were dose-related in both groups. At each dose theF peaks in OB (VLD: 495.6 +/- 43.9 nmol/l, HD: 722.3 +/- 67.7 nmol/l; LD: 519.2 +/- 46.0 nmol/l, HD: 729.6 +/- 44.7 nmol/l) were similar to those in NS (VLD: 556.7 +/- 45.9 nmol/l, HD: 704.8 +/- 20.7 nmol/l; LD: 511.8 +/- 22.8 nmol/l, HD: 726.7 +/- 26.5 nmol/l). The peak A responses to ACTH were dose-related in both groups. At each dose, the A peaks in OB (VLD: 0.55 +/- 0.03 pmol/l, HD: 0.79 +/- 0.09 pmol/l; LD: 0.63 +/- 0.04 pmol/l, HD: 0.78 +/- 0.09 pmol/l) were similar to those in NS (VLD: 0.8 +/- 0.10 pmol/l, HD: 0.86 +/- 0.09 pmol/l; LD: 0.8 +/- 0.10 pmol/l, HD: 0.95 +/- 0.12 pmol/l). The peak DHEA responses to ACTH were dose-related in both groups. At each dose the DHEA peaks in OB (VLD: 58.6 +/- 13.3 nmol/l, HD: 61.9 +/- 13.1 nmol/l; LD: 55.18 +/- 6.4 nmol/l, HD: 72.3 +/- 9.8 nmol/l) were similar to those in NS (VLD: 54.3 +/- 8.2 nmol/l, HD: 57.8 +/- 8.2 nmol/l; LD: 42.2 +/- 3.7 nmol/l, HD: 56.9 +/- 4.3 nmol/l). CONCLUSIONS This study shows that the cortisol, aldosterone and dehydroepiondrosterone responses to high, low and very low ACTH doses in obese women overlap with those in age-matched lean controls; these findings suggest normal sensitivity of the different zones of the adrenal cortex to ACTH in obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 04:02:11