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Titolo:
Heterogeneity in the clinical phenotype of TP53 mutations in breast cancerpatients
Autore:
Alsner, J; Yilmaz, M; Guldberg, P; Hansen, LL; Overgaard, J;
Indirizzi:
Aarhus Univ Hosp, Dept Expt Clin Oncol, Danish Canc Soc, DK-8000 Aarhus C,Denmark Aarhus Univ Hosp Aarhus Denmark C ish Canc Soc, DK-8000 Aarhus C,Denmark Inst Canc Biol, Dept Tumor Cell Biol, DK-2100 Copenhagen, Denmark Inst Canc Biol Copenhagen Denmark DK-2100 l, DK-2100 Copenhagen, Denmark Aarhus Univ Hosp, Dept Oncol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C Dept Oncol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Human Genet, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C Human Genet, DK-8000 Aarhus C, Denmark
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 10, volume: 6, anno: 2000,
pagine: 3923 - 3931
SICI:
1078-0432(200010)6:10<3923:HITCPO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; ZINC-BINDING DOMAINS; GENE; TUMORS; SURVIVAL; PROTEIN; DNA; PROGNOSIS; RECEPTOR; DATABASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Alsner, J Aarhus Univ Hosp, Dept Expt Clin Oncol, Danish Canc Soc, Noerrebrogade 44,Bldg 5, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Noerrebrogade 44,Bldg 5 Aarhus Denmark C nmark
Citazione:
J. Alsner et al., "Heterogeneity in the clinical phenotype of TP53 mutations in breast cancerpatients", CLIN CANC R, 6(10), 2000, pp. 3923-3931

Abstract

TP53 mutation is a strong independent marker for survival in breast cancerwith some heterogeneity in the clinical phenotype of various types of mutations. Based on 315 patients with breast carcinoma, we suggest a new model for the differentiation of TP53 mutations, Although TP53 mutation in general was associated with aggressive tumor/patient characteristics, missense mutations outside any conserved or structural domain did not affect the clinical outcome (risk of disseminated disease and death), In contrast, patientswith missense mutations affecting amino acids directly involved in DNA or zinc binding displayed a very aggressive clinical phenotype, Null mutations(including missense mutations disrupting the tetramerization domain) and the remaining missense mutations displayed an intermediate aggressive clinical phenotype, When patients with primary early breast cancer were divided into three groups (wild-type together with missense mutations outside structural/conserved domains, null mutations and missense mutations with intermediate clinical phenotype, and very aggressive missense mutations), disease-specific survival rates were 89%, 58%, and 35% (5-year actuarial values, P <0.0001), respectively, In a Cox proportional hazards analysis, separation of TP53 mutations according to these criteria eliminated the prognostic importance of all investigated classical factors except nodal status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:03:10