Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cellular uptake of long-chain fatty acids: role of membrane-associated fatty-acid-binding/transport proteins
Autore:
Dutta-Roy, AK;
Indirizzi:
Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 10, volume: 57, anno: 2000,
pagine: 1360 - 1372
SICI:
1420-682X(200009)57:10<1360:CUOLFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE; HIGH-DENSITY-LIPOPROTEIN; LIVER PLASMA-MEMBRANES; ACYL-COA SYNTHETASE; BINDING-PROTEIN; TRANSPORT PROTEIN; HUMAN PLACENTA; RAT-LIVER; HUMAN CD36; MONOCYTES MACROPHAGES;
Keywords:
plasma membrane fatty-acid-binding protein (FABP(pm)); fatty acid translocase (FAT); fatty acid transporter protein (FATP); free fatty acid (FFA); fatty acid uptake; long-chain polyunsaturated fatty acids (LCPUFAs); long-chain fatty acids (LCFAs);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Dutta-Roy, AK Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB 1 9SB, Scotland
Citazione:
A.K. Dutta-Roy, "Cellular uptake of long-chain fatty acids: role of membrane-associated fatty-acid-binding/transport proteins", CELL MOL L, 57(10), 2000, pp. 1360-1372

Abstract

The critical importance of long-chain fatty acids in cellular homeostasis demands an efficient uptake system for these fatty acids and their metabolism in tissues. Increasing evidence suggests that the plasmamembrane-associated and cytoplasmic fatty-acid-binding proteins are involved in cellular fatty acid uptake, transport and metabolism in tissues. These binding proteins may also function in the fine tuning of cellular events by modulating themetabolism of long-chain fatty acids implicated in the regulation of cell growth and various cellular functions. Several membrane-associated fatty-acid-binding/transport proteins such as plasma membrane fatty-acid-binding protein (FABP(pm), 43 kDa), fatty acid translocase (FAT, 881 kDa) and fatty acid transporter protein (FATP, 63 kDa) have been identified. In the fete-placental unit, preferential transport of maternal plasma arachidonic and docosahexaenoic acids across the placenta is of critical importance for fetal growth and development. Our studies have shown that arachidonic and docosahexaenoic acids are preferentially taken up by placental trophoblasts for fetal transport. The existence of a fatty-acid-transport system comprising multiple membrane-binding proteins (FAT, FATP and FABP(pm)) in human placentamay be essential to facilitate the preferential transport of maternal plasma fatty acids in order to meet the requirements of the growing fetus. The preferential uptake of arachidonic and docosahexaenoic acids by the human placenta has the net effect of shunting these maternal plasma fatty acids towards the fetus. The roles of plasma membrane-associated binding/transport proteins (FABP(pm), FAT and FATP) in tissue-specific fatty acid uptake and metabolism are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:24:22