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Titolo:
Effects of tamoxifen on the electron transport chain of isolated rat livermitochondria
Autore:
Tuquet, C; Dupont, J; Mesneau, A; Roussaux, J;
Indirizzi:
Univ Paris 06, Lab Biol Cellulaire Vegetale, F-75005 Paris, France Univ Paris 06 Paris France F-75005 laire Vegetale, F-75005 Paris, France
Titolo Testata:
CELL BIOLOGY AND TOXICOLOGY
fascicolo: 4, volume: 16, anno: 2000,
pagine: 207 - 219
SICI:
0742-2091(2000)16:4<207:EOTOTE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C OXIDASE; BREAST-CANCER; RESPIRATORY-CHAIN; CARDIOLIPIN REQUIREMENT; COMPLEX-III; HYDROXYTAMOXIFEN; ADRIAMYCIN; PREVENTION; DITERCALINIUM; METABOLISM;
Keywords:
electron transport chain; isolated mitochondria; rat liver; tamoxifen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tuquet, C Univ Paris 06, Lab Biol Cellulaire Vegetale, 12 Rue Cuvier, F-75005 Paris,France Univ Paris 06 12 Rue Cuvier Paris France F-75005 5 Paris,France
Citazione:
C. Tuquet et al., "Effects of tamoxifen on the electron transport chain of isolated rat livermitochondria", CELL BIOL T, 16(4), 2000, pp. 207-219

Abstract

Tamoxifen (and 4-hydroxytamoxifen), a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment of breast cancer, interacts strongly with the respiratory chain of isolated rat liver mitochondria. The drug acts as both an uncoupling agent and a powerful inhibitor of electron transport. Tamoxifen brings about a collapse of the membrane potential. Enzymatic assays and spectroscopic studies indicate that tamoxifen inhibits electron transfer in the respiratory chain at the levels of complex III (ubiquinol-cytochrome-c reductase) and, to a lesser extent, of complex IV (cytochrome-c oxidase). The activities can be restored by the addition of diphosphatidylglycerol, a phospholipid implicated in the functioning of the respiratory chain complexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:18:23