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Titolo:
Distribution of alpha v beta 3, alpha v beta 5 integrins and the integrin associated protein - IAP (CD47) in human glomerular diseases
Autore:
Hafdi, Z; Lesavre, P; Nejjari, M; Halbwachs-Mecarelli, L; Droz, D; Noel, LH;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U507, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 507, F-75015 Paris, France Hop Necker Enfants Malad, INSERM, Dept Nephrol, F-75743 Paris 15, France Hop Necker Enfants Malad Paris France 15 phrol, F-75743 Paris 15, France Hop Edouard Herriot, INSERM, U45, F-69003 Lyon, France Hop Edouard Herriot Lyon France F-69003 NSERM, U45, F-69003 Lyon, France
Titolo Testata:
CELL ADHESION AND COMMUNICATION
fascicolo: 6, volume: 7, anno: 2000,
pagine: 441 -
SICI:
1061-5385(2000)7:6<441:DOAVB3>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-ENDOTHELIAL-CELLS; ADHESION MOLECULES; ALPHA(V) INTEGRINS; BETA-1 INTEGRINS; MATRIX RECEPTORS; GLOMERULONEPHRITIS; VITRONECTIN; EXPRESSION; DIFFERENTIATION; THROMBOSPONDIN;
Keywords:
mesangial cells; glomerulonephritis; integrins; alpha v beta 3; alpha v beta 5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Hafdi, Z Hop Necker Enfants Malad, INSERM, U507, 161 Rue Sevres, F-75015 Paris, France Hop Necker Enfants Malad 161 Rue Sevres Paris France F-75015 nce
Citazione:
Z. Hafdi et al., "Distribution of alpha v beta 3, alpha v beta 5 integrins and the integrin associated protein - IAP (CD47) in human glomerular diseases", CELL AD COM, 7(6), 2000, pp. 441

Abstract

The alpha v integrins present on the membrane of numerous cells, mediate attachment to matrix proteins, cell proliferation, migration and survival. We studied the expression of alpha v integrins and CD47 (a beta 3 chain integrin associated protein) in various forms of glomerulonephritis (GN) characterized by mesangial proliferation and/or increased mesangial matrix. In normal glomeruli, epithelial cells expressed av beta 3, alpha v beta 5 and CD47; endothelial cells expressed alpha 5 beta 1 and CD47, mesangial cells expressed alpha v beta 5, CD47, and to a less extent alpha v beta 3. In acutepost infectious GN (APIGN), membranoproliferative GN (MPGN) and diabetic nephropathy (DN), we observed that the beta 3 chain, normally expressed by mesangial cells, was not detectable in the mesangium while its expression byepithelial cells was not modified. Parallel to the disappearance of alpha v beta 3. the CD47 expression was decreased on the mesangial cells in MPGN,APIGN and DN. The expression of alpha v beta 5 was clearly increased on podocytes and on proliferating mesangial cells in APIGN. By contrast, the mesangial expression of alpha v beta 5 was normal or decreased in DN, The alpha 5 chain of integrin, absent on normal mesangial cell, was expressed on proliferating mesangial cells in MPGN and APIGN. Thus, we observed modifications of alpha v beta 3 and alpha v beta 5 expression during human GN. The modulations of alpha v beta 3 and alpha v beta 5expression differed according to the different glomerular cell types and were not parallel in glomerular cells: alpha v beta 3 was decreased land alpha v beta 5 unchanged) on proliferating mesangial cells and alpha v beta 5 was increased land alpha v beta 3 unchanged) in podocytes. This may reflectthe existence of two distinct regulatory pathways.

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Documento generato il 15/07/20 alle ore 08:35:27