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Titolo:
Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in ratbrain
Autore:
ODonnell, T; Rotzinger, S; Nakashima, TT; Hanstock, CC; Ulrich, M; Silverstone, PH;
Indirizzi:
Univ Alberta, Dept Psychiat, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 iat, Edmonton, AB T6G 2B7, Canada Univ Alberta, Dept Chem, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 hem, Edmonton, AB T6G 2B7, Canada
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 880, anno: 2000,
pagine: 84 - 91
SICI:
0006-8993(20001013)880:1-2<84:CLASVB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; SIGNAL-TRANSDUCTION PATHWAYS; MOOD-STABILIZING AGENTS; PROTEIN-KINASE-C; PHOSPHOINOSITIDE METABOLISM; PHOSPHORUS-METABOLISM; STATUS EPILEPTICUS; N-ACETYLASPARTATE; BIPOLAR DISORDER; GENE-EXPRESSION;
Keywords:
lithium; sodium valproate; myo-inositol; inositol monophosphates; creatine; N-acetylaspartate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Silverstone, PH Univ Alberta, Dept Psychiat, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G 2B7 B T6G 2B7, Canada
Citazione:
T. O'Donnell et al., "Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in ratbrain", BRAIN RES, 880(1-2), 2000, pp. 84-91

Abstract

One of the mechanisms underlying lithium's efficacy as a mood stabilizer in bipolar disorder has been proposed to be via its effects on the phosphoinositol cycle (PI-cycle), when it is an inhibitor of thr enzyme converting inositol monophosphates to myo-inositol. In contrast, sodium valproate, another commonly used mood stabilizer, appears to have no direct effects on this enzyme and was thus believed to have a different mechanism of action. In the present study, high resolution nuclear magnetic resonance (NMR) spectroscopy was used to study the chronic effects of both lithium and sodium valproate on the concentrations of myo-inositol and inositol monophosphates in rat brain. As predicted, lithium-treated rats exhibited a significant increase in the concentration of inositol monophosphates and a significant decrease in myo-inositol concentration compared to saline-treated controls. However, unexpectedly, sodium valproate administration produced exactly the same results as lithium administration. These novel findings suggest that bothlithium and sodium valproate may share a common mechanism of action in thetreatment of bipolar disorder via actions on the PI-cycle. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:49:50