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Titolo:
Polycarboxylates inhibit the glucan-binding lectin of Streptococcus sobrinus
Autore:
Goh, CT; Taweechaisupapong, S; Taylor, KG; Doyle, RJ;
Indirizzi:
Univ Louisville, Hlth Sci Ctr, Dept Microbiol & Immunol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Immunol, Louisville, KY 40292 USA Khon Kaen Univ, Fac Dent, Khon Kaen, Thailand Khon Kaen Univ Khon Kaen Thailand n Univ, Fac Dent, Khon Kaen, Thailand Univ Louisville, Dept Chem, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 pt Chem, Louisville, KY 40292 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
fascicolo: 1, volume: 1523, anno: 2000,
pagine: 111 - 116
SICI:
0304-4165(20000901)1523:1<111:PITGLO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-1,6 GLUCANS; CARBOXYL GROUPS; CRICETUS; AGGREGATION; HYALURONAN; BACTERIA; IONS; ACID;
Keywords:
lectin; glucan; hyaluronate; carboxymethylcellulose; Streptococcus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Doyle, RJ Univ Louisville, Hlth Sci Ctr, Dept Microbiol & Immunol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ouisville, KY 40292 USA
Citazione:
C.T. Goh et al., "Polycarboxylates inhibit the glucan-binding lectin of Streptococcus sobrinus", BBA-GEN SUB, 1523(1), 2000, pp. 111-116

Abstract

Polycarboxylates, such as carboxymethylcellulose and hyaluronan, were found to be reversible inhibitors of the glucan-binding lectin of Streptococcussabrinus. When the carboxylate groups were coupled to ethylenediamine, or reduced with carbodiimide-borohydride, inhibitory powers were lost. Similarly, N-deacetylated hyaluronan had poor inhibitory powers, probably due to the introduction of positive charges into the polymer. Other polymers, such as chondroitin sulfates, dextran sulfate, fetuin, heparin were not inhibitors. It appears that inhibition is based on repeating carboxylates, free of influence from ammonium groups. Such polymers have the property of complexing with metals. Earlier studies had concluded that the streptococcal lectindepended on manganese for activity. It is likely the carboxymethylcellulose and hyaluronan perturb essential metal coordination centers in the lectin. Polycarboxylates may have value in oral health care by acting on glucan-dependent microbial adhesion and biofilm formation. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:01:18