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Titolo:
THE ROLE OF NITRIC-OXIDE IN CARDIAC-SURGERY
Autore:
NONAMI Y;
Indirizzi:
KOCHI MED SCH,DEPT SURG 2 NANKOKU KOCHI 783 JAPAN
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 7, volume: 27, anno: 1997,
pagine: 583 - 592
SICI:
0941-1291(1997)27:7<583:TRONIC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; SELECTIVE PULMONARY VASODILATOR; ENDOTHELIUM-DEPENDENT RELAXATIONS; GRAFT INTIMAL HYPERPLASIA; CONGENITAL HEART-DEFECTS; REDUCES INFARCT SIZE; L-ARGININE; MYOCARDIAL-ISCHEMIA; RELAXING FACTOR; AGGREGATING PLATELETS;
Keywords:
NITRIC OXIDE; MYOCARDIAL REPERFUSION INJURY; CARDIAC SURGERY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nonami, "THE ROLE OF NITRIC-OXIDE IN CARDIAC-SURGERY", SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 27(7), 1997, pp. 583-592

Abstract

The release of nitric oxide (NO) from coronary endothelial cells is impaired following reperfusion; however, several experimental studies have found that it exerts a cardioprotective effect during myocardial ischemia-reperfusion, Thus, attempts have been made to supplement NO production exogenously during reperfusion when endogenous NO release maybe diminished, Conversely, other studies suggest that NO exacerbates reperfusion injury by inducing the production of peroxynitrite. NO hasalso been reported to provide beneficial effects as a selective pulmonary vasodilator to relieve pulmonary hypertension, A loss of NO-mediated relaxation caused by the dysfunction of endothelial cells is characteristic of intimal hyperplasia, and nitrosovasodilators have proven efficient against atherosclerotic coronary heart disease, which may beattributable to their antiplatelet effects as well as to vasodilation, Furthermore, protamine sulfate, which is rich in L-arginine, is thought to augment NO production by supplying exogenous L-arginine, or to act on endothelial cell receptors to stimulate the production of NO. This review summarizes the current role of NO in cardiac surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:17:18