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Titolo:
Ototoxic interaction between noise and pheomelanin: Distortion product otoacoustic emissions after acoustical trauma in chloroquine-treated red, black, and albino guinea pigs
Autore:
Barrenas, ML; Holgers, KM;
Indirizzi:
Gothenburg Univ, Sahlgrens Hosp, Dept Audiol, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 ol, S-41345 Gothenburg, Sweden
Titolo Testata:
AUDIOLOGY
fascicolo: 5, volume: 39, anno: 2000,
pagine: 238 - 246
SICI:
0020-6091(200009/10)39:5<238:OIBNAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; TEMPORARY THRESHOLD SHIFT; INNER-EAR; MELANIN; HAIR; GLUTATHIONE; EUMELANIN; HUMANS; ANTIOXIDANT; EXPRESSION;
Keywords:
noise-induced hearing loss; cochlea; melanin; pigment; chloroquine; stria vascularis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Barrenas, ML Gothenburg Univ, Sahlgrens Hosp, Dept Audiol, Grona Straket 11, S-41345 Gothenburg, Sweden Gothenburg Univ Grona Straket 11 Gothenburg Sweden S-41345 n
Citazione:
M.L. Barrenas e K.M. Holgers, "Ototoxic interaction between noise and pheomelanin: Distortion product otoacoustic emissions after acoustical trauma in chloroquine-treated red, black, and albino guinea pigs", AUDIOLOGY, 39(5), 2000, pp. 238-246

Abstract

This study provides further evidence of an ototoxic interaction between red pheomelanin pigmentation and noise-induced hearing loss. Red, black, and albino guinea pigs were treated with a low, a high, or no dose of chloroquine. The 2f(1)-f(2) distortion product otoacoustic emission (DPOE) measurements were measured before, immediately after, and 1 month after noise exposure to a 1-kHz tone at 105 dB SPL for 72 hours. In red guinea pigs, the DPOEwas severely affected by noise trauma when treated even by a low single dose of chloroquine, whereas in both albino and black guinea pigs, the chloroquine effect on the DPOE was temporary and present only when the drug was given in a high single dose. The structure most likely to be responsible forthe severe loss of DPOE in chloroquine-treated red animals is the strial melanocyte. The damage may be triggered by an ototoxic noise-induced production of radical oxygen species from pheomelanin, for example, by the Fenton reaction or due to the increased variability of the melanocyte 1 receptor gene as in red-haired individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:33:09