Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antigen-presenting cells - Experimental and clinical studies of dendritic cells
Autore:
Austyn, JM;
Indirizzi:
John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Surg, Oxford OX3 9DU, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 162, anno: 2000, supplemento:, S
pagine: S146 -
SICI:
1073-449X(200010)162:4<S146:AC-EAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOKINES; VACCINATION; TRAFFICKING; MATURATION; INFECTION; IMMUNITY; HIV-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Austyn, JM John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU d OX3 9DU, England
Citazione:
J.M. Austyn, "Antigen-presenting cells - Experimental and clinical studies of dendritic cells", AM J R CRIT, 162(4), 2000, pp. S146

Abstract

We present a summary of our experimental and clinical studies of dendriticcells (DCs) in five different areas. First, human DCs undergo chemotaxis and transendothelial migration in response to distinct chemokines, dependingon their maturation state; inducible chemokines may recruit immature DCs to sites of inflammation and infection, whereas constitutive chemokines may regulate subsequent migration to lymphoid tissues. Second, M-tropic but notT-tropic strains of HIV-1 induce and modulate DC chemotaxis in culture; conceivably this may facilitate viral infection and contribute to pathogenesis in vivo. Third, malaria-infected erythrocytes modulate the maturation andinhibit the function of DCs; adhesion of infected erythrocytes to DCs may impart a selective advantage to the parasite by modulating host immunity. Fourth, a phase I clinical trial of DC-based immunotherapy of cancer has been initiated in which autologous DCs are administered directly into metastatic skin lesions; immune responses to a recall antigen, with which the cellswere pulsed, were enhanced in several patients. Finally we describe the growth and characterization of a stably immature, maturation-resistant stage of DCs generated from mouse bone marrow that can induce transplantation tolerance in vivo, and outline studies of their capacity to induce responses of transgenic T cells in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 09:41:20