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Titolo:
Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension - Effect of prostacyclin therapy
Autore:
Eddahibi, S; Humbert, M; Sediame, S; Chouaid, C; Partovian, C; Maitre, B; Teiger, E; Rideau, D; Simonneau, C; Sitbon, O; Adnot, S;
Indirizzi:
Hop Henri Mondor, Serv Physiol, Dept Physiol, AP HP, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 , AP HP, F-94010 Creteil, France Hop Henri Mondor, INSERM, U492, AP HP, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 , AP HP, F-94010 Creteil, France Hop Antoine Beclere, Serv Pneumol, AP HP, Clamart, France Hop Antoine Beclere Clamart France Serv Pneumol, AP HP, Clamart, France Hop Intercommunal, Serv Pneumol, Creteil, France Hop Intercommunal Creteil France ommunal, Serv Pneumol, Creteil, France
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 162, anno: 2000,
pagine: 1493 - 1499
SICI:
1073-449X(200010)162:4<1493:IBPVEG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PLATELETS; LUNG-DISEASE; EXPRESSION; RELEASE; VEGF; CELLS; GENE; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Adnot, S Hop Henri Mondor, Serv Physiol, Dept Physiol, AP HP, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 F-94010 Creteil, France
Citazione:
S. Eddahibi et al., "Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension - Effect of prostacyclin therapy", AM J R CRIT, 162(4), 2000, pp. 1493-1499

Abstract

Focal vascular injury and impaired endothelial function are features of pulmonary hypertension (PH) that lead to enhanced platelet endothelial cell interactions. Vascular endothelial growth factor (VEGF) is contained in platelets and released at sites of vascular injury to promote endothelial repair and wound healing in combination with platelet-derived nonspecific mitogens such as platelet-derived growth factor (PDGF). The overall balance between platelet VEGF and PDGF was investigated in 21 patients with primary PH, 8 with secondary PH, and 27 with chronic hypoxemic lung disease (CHLD), as well as in 29 control subjects. Platelet VEGF content was increased in patients with primary and secondary PH as compared with control subjects (518 +/- 89, 675 +/- 156, and 166 +/- 29 fg/10(5) platelets, respectively; p < 0.01), whereas platelet PDGF content was similar in the three groups (31 +/- 2, 36 +/- 4, and 33 +/- 3 pg/10(5) platelets, respectively; NS). Patients treated with a continuous prostacyclin infusion had a higher platelet VEGF but a similar platelet PDGF content as compared with untreated patients. Moderate increases in platelet VEGF and PDGF contents were observed in the CHLD patients. We conclude that patients with primary or secondary PH have an increase in platelet VEGF content, but not in platelet PDGF content, and that their platelet VEGF content increases further in response to prostacyclin infusion. We suggest that imbalance between platelet VEGF and PDGF is beneficial to patients with PH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:47:18