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Titolo:
Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease
Autore:
Engelen, MPKJ; Deutz, NEP; Wouters, EFM; Schols, AMWJ;
Indirizzi:
Maastricht Univ, Dept Pulm, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Pulm, Maastricht, Netherlands Maastricht Univ, Dept Surg, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Surg, Maastricht, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 162, anno: 2000,
pagine: 1488 - 1492
SICI:
1073-449X(200010)162:4<1488:ELOWPT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-CONCENTRATIONS; NUTRITIONAL-STATUS; KINETICS; METABOLISM; EMPHYSEMA; PLASMA; HUMANS; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Engelen, MPKJ Univ Hosp Maastricht, Dept Pulm, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M.P.K.J. Engelen et al., "Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease", AM J R CRIT, 162(4), 2000, pp. 1488-1492

Abstract

A substantial number of patients with chronic obstructive pulmonary disease (COPD) are characterized by fat-free mass wasting and altered muscle and plasma amino acid levels, suggesting changes in protein metabolism. In the present study, we examined whether whole-body protein breakdown (PB) and synthesis (PS) differ between 14 stable patients with COPD and 8 healthy controls. Whole-body PB, PS, and net PB (= PB-PS) were measured by the combinedInfusion of the stable isotopes L-[ring-H-2(5)]phenylalanine (Phe) and L-[ring-H-2(2)]tyrosine. Because there is evidence for specific disturbances in leucine (Leu) metabolism, the PB values were compared with those obtainedwhen infusing L-[1-C-13]Leu tracer. In arterialized-venous plasma and in vastus lateralis muscle, the isotope enrichment values and amino acid concentrations were measured. Whole-body PS and PB, assessed by Phe and Tyr tracer, were higher in the COPD group than in the control group (p < 0.05), indicating an elevated protein turnover. Net PB was increased in both groups, indicating a comparable degree of protein catabolism in the postabsorptive state. In contrast, whole-body PB determined by Leu tracer was not differentbetween the groups. As a consequence, the ratio of Leu to Phe breakdown was reduced in the COPD group (p < 0.001). Moreover, in the COPD group a higher muscle-to-plasma gradient was found for Leu (p < 0.001) but not for Phe. The present study reveals elevated levels for protein turnover in patientswith COPD, and indicates that infusion of the Leu tracer gives a reflection of Leu metabolism but not of whole-body protein metabolism in these patients.

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Documento generato il 08/07/20 alle ore 06:31:15