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Titolo:
Exercise-induced bronchoconstriction does not cause eosinophilic airway inflammation or airway hyperresponsiveness in subjects with asthma
Autore:
Gauvreau, GM; Ronnen, GM; Watson, RM; OByrne, PM;
Indirizzi:
St Josephs Hosp, Firestone Chest & Allergy Unit, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada er Univ, Dept Med, Hamilton, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 162, anno: 2000,
pagine: 1302 - 1307
SICI:
1073-449X(200010)162:4<1302:EBDNCE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGEN-INDUCED BRONCHOCONSTRICTION; LEUKOTRIENE RECEPTOR ANTAGONIST; MAST-CELL ACTIVATION; BRONCHIAL RESPONSIVENESS; SYMPTOMATIC ASTHMA; ATOPIC ASTHMATICS; INHALED PGE(2); SPUTUM; CHALLENGE; HISTAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: O'Byrne, PM St Josephs Hosp, Firestone Chest & Allergy Unit, Room R113,50 Charlton AveE, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Room R113,50 Charlton Ave E Hamilton ON Canada L8N 4A6
Citazione:
G.M. Gauvreau et al., "Exercise-induced bronchoconstriction does not cause eosinophilic airway inflammation or airway hyperresponsiveness in subjects with asthma", AM J R CRIT, 162(4), 2000, pp. 1302-1307

Abstract

The cysteinyl leukotrienes (LT) C-4, D-4, and E-4 may partially mediate eosinophilic airway inflammation in patients with asthma, High-intensity exercise by patients with asthma can result in exercise-induced bronchoconstriction, partly due to leukotriene production, but it is still debated whetherthis causes airway inflammation. Ten subjects completed a randomized, controlled study to examine the effects of exercise-induced bronchoconstrictionon airway inflammatory cells. Subjects completed exercise challenge and methacholine challenge in random order separated by 1 wk. Spirometry was measured for 2 h after challenges, and airway responsiveness was measured the day before and 24 h after each challenge. Blood and sputum samples were obtained before, and 2, 4, 7, and 24 h after each challenge for measurement of inflammatory cells. Nine of the subjects inhaled allergen at least 3 wk before or 1 wk after the study. Sputum samples were collected before, 7 h, and24 h after challenge. The maximum percentage fall in FEV1 was 21.3 +/- 1.5% after exercise, 29.9 +/- 1.5% after methacholine, and 28.9+/-2.7% after allergen. Exercise had no effect on airway responsiveness or inflammatory cells measured in blood or sputum, unlike allergen inhalation, which resultedin significant airway hyperresponsiveness and increases in sputum eosinophils (p < 0.05). This study demonstrates that exercise-induced bronchoconstriction does not cause eosinophilic airway inflammation in subjects with asthma who develop airway inflammation with the same degree of allergen-induced bronchoconstriction. We conclude that exercise-induced bronchoconstriction does not cause airway inflammation or airway hyperresponsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 03:31:01