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Titolo:
Accuracy and utility of commercially available amplification and serologictests for the diagnosis of minimal pulmonary tuberculosis
Autore:
Al Zahrani, K; Al Jahdali, H; Poirier, L; Rene, P; Gennaro, ML; Menzies, D;
Indirizzi:
McGill Univ, Royal Victoria Hosp, Dept Microbiol, Montreal Chest Inst,RespEpidemiol Unit, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Unit, Montreal, PQ H3A 1A1, Canada Univ Montreal, Hop Maison Neuve Rosemont, Montreal, PQ, Canada Univ Montreal Montreal PQ Canada on Neuve Rosemont, Montreal, PQ, Canada Publ Hlth Res Inst, New York, NY USA Publ Hlth Res Inst New York NY USAPubl Hlth Res Inst, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 162, anno: 2000,
pagine: 1323 - 1329
SICI:
1073-449X(200010)162:4<1323:AAUOCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ACID-FAST BACILLI; MYCOBACTERIUM-TUBERCULOSIS; RESPIRATORY SPECIMENS; SERODIAGNOSIS; ELISA; ASSAY; ANTIBODY; ANTIGEN; SMEARS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Menzies, D Montreal Chest Inst, 3650 St Urbain St, Montreal, PQ H2X 2P4, Canada Montreal Chest Inst 3650 St Urbain St Montreal PQ Canada H2X 2P4
Citazione:
K. Al Zahrani et al., "Accuracy and utility of commercially available amplification and serologictests for the diagnosis of minimal pulmonary tuberculosis", AM J R CRIT, 162(4), 2000, pp. 1323-1329

Abstract

Diagnosis of patients with minimal active tuberculosis (TB) is difficult, as there is no single test with high sensitivity and specificity. The yieldand clinical utility of a combination of diagnostic tests were prospectively studied among 500 consecutive patients referred for sputum induction fordiagnosis of possible active TB. Patients underwent sputum induction, chest X-ray, tuberculin testing, and had blood drawn for serologic testing (Detect-TB test; Biochem ImmunoSystems). Sputum was examined with fluorescent microscopy and PCR (Amplicor MTB-Roche) and cultured for mycobacteria using liquid (BACTEC) and solid media. For the diagnosis of the 60 cases of active TB, sensitivity and specificity, respectively, of the following diagnostic tests were mycobacterial culture, 73% and 100%; PCR, 42% and 100%; chest X-ray, 67-77% and 66-76%; tuberculin testing, 94% and 20%; and serology, 33% and 87%. After consideration of PCR and radiographic and clinical characteristics, a positive serologic test was independantly associated with diagnosis of active disease (adjusted odds of disease if positive, 2.6; 95% confidence limits, 1.1,6.1). No currently available test has sensitivity and specificity high enough for the accurate diagnosis of minimal pulmonary TB. Utilization of a combination of tests, together with consideration of key clinical characteristics, could improve diagnostic accuracy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:05:55