Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NAALADase inhibition reduces alcohol consumption in the alcohol-preferring(P) line of rats
Autore:
McKinzie, DL; Li, TK; McBride, WJ; Slusher, BS;
Indirizzi:
Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ychiat, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ, Sch Med, Dept Biochem, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iochem, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Inst Psychiat Res, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 at Res, Indianapolis, IN 46202 USA Guilford Pharmaceut Inc, Dept Res, Indianapolis, IN USA Guilford Pharmaceut Inc Indianapolis IN USA pt Res, Indianapolis, IN USA
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 5, anno: 2000,
pagine: 411 - 416
SICI:
1355-6215(200010)5:4<411:NIRACI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED ACIDIC DIPEPTIDASE; ETHANOL WITHDRAWAL SEIZURES; NMDA RECEPTOR ANTAGONIST; N-ACETYLASPARTYLGLUTAMATE; GLUTAMATERGIC NEUROTRANSMISSION; EXCITATORY NEUROTRANSMISSION; CEREBRAL-CORTEX; SELF-INFUSION; MESSENGER-RNA; ACAMPROSATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Slusher, BS Guilford Pharmaceut Inc, 6611 Tributary St, Baltimore, MD 21224 USA Guilford Pharmaceut Inc 6611 Tributary St Baltimore MD USA 21224
Citazione:
D.L. McKinzie et al., "NAALADase inhibition reduces alcohol consumption in the alcohol-preferring(P) line of rats", ADDICT BIOL, 5(4), 2000, pp. 411-416

Abstract

N-acetyl-aspartyl-glutamate (NAAG) is a major peptide component of the brain, with millimolar tissue levels of 0.1-5 nmol/mg wet weight. NAAG is hydrolyzed by the enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase; glutamate carboxypeptidase II; EC no. 3.4.17.21) to N-acetyl-aspartate (NAA) and glutamate. Recently, a potent and selective NAALADase inhibitor ter med 2-(phosphonomethyl)pentane-dioic acid (2-PMPA) was identified that has a 300 pM Ki for NAALADase inhibition. Given the accumulating evidence indicating an important role of the glutamate system in alcoholism and dependence, the objective of this study was to evaluate the effects of systemic administration of 2-PMPA (50, 100 and 200 mg/kg; i.p.) upon the ethanol intakes of alcohol-preferring (P) rats. Female P rats (n = 8) received daily 1-hour scheduled access to a 10% (v/v) ethanol. In a within-subjects design, 2-PMPA treatments were tested once a week. Baseline ethanol dr inking consisted of the mean of the 3 days prior to testing in which saline injections were given. Results indicated that, whereas the 200 mg/kg dose of 2-PMPA hadno effect on ethanol intake, both the 50 and 100 mg/kg doses significantlyreduced ethanol consumption by approximately 25% (p < 0.05) during the 1-hour access period. Body weights and 24-hour water intakes were not altered at any of the doses. These data suggest that the NAAG/NAALADase system may be involved in neuronal systems regulating alcohol-drinking behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:57:15