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Titolo:
Amyloid beta-protein (A beta)-containing astrocytes are located preferentially near N-terminal-truncated alpha beta deposits in the human entorhinal cortex
Autore:
Thal, DR; Schultz, C; Dehghani, F; Yamaguchi, H; Braak, H; Braak, E;
Indirizzi:
Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 nat, D-60590 Frankfurt, Germany Gunma Univ, Sch Hlth Sci, Gunma 3718514, Japan Gunma Univ Gunma Japan 3718514 Univ, Sch Hlth Sci, Gunma 3718514, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 6, volume: 100, anno: 2000,
pagine: 608 - 617
SICI:
0001-6322(200012)100:6<608:AB(BAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-RELATED PROTEIN; FIBRILLARY ACIDIC PROTEIN; ALZHEIMERS-DISEASE; A-BETA; GLIAL-CELLS; DIFFUSE PLAQUES; NEUROFIBRILLARY CHANGES; APOLIPOPROTEIN-E; SENILE PLAQUES; BRAIN;
Keywords:
amyloid beta-protein; amyloid beta-protein precursor; astrocytes; Alzheimer's disease; fleecy amyloid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Thal, DR Univ Frankfurt, Dept Anat, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 any
Citazione:
D.R. Thal et al., "Amyloid beta-protein (A beta)-containing astrocytes are located preferentially near N-terminal-truncated alpha beta deposits in the human entorhinal cortex", ACT NEUROP, 100(6), 2000, pp. 608-617

Abstract

The deposition of the amyloid beta -protein (A beta) is a pathological hallmark of Alzheimer's disease (AD). A beta is a peptide consisting of 39-43 amino acids and is derived by beta- and gamma -secretase cleavage from the AP protein precursor (A beta PP). An N-terminal-truncated form of A beta can occur following alpha- and gamma -secretase cleavage of A beta PP. Fleecyamyloid is a recently identified distinct type of A beta deposits occurring in the internal layers (pri-alpha, pri-beta and pri-gamma) of the human entorhinal cortex. Fleecy amyloid consists exclusively of N-terminal-truncated A beta and is a transient form of A beta deposits, which disappears in late-stage beta -amyloidosis. In this study, the entorhinal cortex of 15 cases with AD-related pathology was used to examine astrocytes in the vicinityof N-terminal-truncated A beta in fleecy amyloid of the layers pri-alpha, pri-beta, and pri-gamma in comparison to astrocytes in the vicinity of full-length A beta in layers pre-beta and pre-gamma. Immunohistochemistry was performed with antibodies directed against A beta PP, A beta (40), A beta (42), A beta (17-24) A beta (1-17) and A beta (8-17) as well as by double-labeling with antibodies directed against A beta (17-24) A beta (42), and glial fibrillary acid protein (GFAP). A large number of GFAP-positive astrocytes containing N-terminal-truncated A beta fragments appeared in the vicinityof N-terminal-truncated A beta, whereas A beta -containing astrocytes wererarely seen in the vicinity of full-length A beta. These results suggest that N-terminal-truncated A beta peptide may be cleared preferentially from the extracellular space by astrocytic uptake and processing. Such an astroglial uptake of N-terminal-truncated A beta may account for the transient nature of fleecy amyloid and point to the use of N-terminal truncation of A beta in potential therapeutic strategies aimed at preventing the brain from amassing full-length A beta deposits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:26:44