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Titolo:
Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris
Autore:
Olivry, T; Alhaidari, Z; Ghohestani, RF;
Indirizzi:
N Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC 27606 USA N Carolina State Univ Raleigh NC USA 27606 lin Sci, Raleigh, NC 27606 USA
Titolo Testata:
VETERINARY PATHOLOGY
fascicolo: 5, volume: 37, anno: 2000,
pagine: 496 - 499
SICI:
0300-9858(200009)37:5<496:AADAIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARANEOPLASTIC PEMPHIGUS; DESMOSOMAL PLAQUE; FOLIACEUS; IDENTIFICATION; TARGET; CANINE;
Keywords:
dogs; lung; microcystic hamartoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Olivry, T N Carolina State Univ, Coll Vet Med, Dept Clin Sci, 4700 Hillsborough St, Raleigh, NC 27606 USA N Carolina State Univ 4700 Hillsborough St Raleigh NC USA 27606
Citazione:
T. Olivry et al., "Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris", VET PATH, 37(5), 2000, pp. 496-499

Abstract

Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retrieverbecause of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and -3) antigens. Necropsy, however, failed to confirm the concurrent existenceof hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected inanother form of suprabasal pemphigus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:15:16