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Titolo:
Effect of amphetamine on extrastriatal D2 dopamine receptor binding in theprimate brain: A PET study
Autore:
Chou, YH; Halldin, C; Farde, L;
Indirizzi:
Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, Karolinska Inst, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Inst, S-17176 Stockholm, Sweden
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 38, anno: 2000,
pagine: 138 - 143
SICI:
0887-4476(200011)38:2<138:EOAOED>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; RAT PREFRONTAL CORTEX; ENDOGENOUS DOPAMINE; SYNAPTIC DOPAMINE; D-2-DOPAMINE RECEPTORS; NONHUMAN-PRIMATES; D1 RECEPTORS; SCHIZOPHRENIA; RELEASE;
Keywords:
endogenous dopamine; positron emission tomography (PET); amphetamine; [C-11]FLB 457; D2 dopamine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Chou, YH Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, Karolinska Inst, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 7176 Stockholm, Sweden
Citazione:
Y.H. Chou et al., "Effect of amphetamine on extrastriatal D2 dopamine receptor binding in theprimate brain: A PET study", SYNAPSE, 38(2), 2000, pp. 138-143

Abstract

[C-11]raclopride binding to D2 dopamine receptors in the striatum is sensitive to drug-induced changes of endogenous dopamine concentration. We recently developed the new radioligand [C-11]FLB 457, which is suitable for positron emission tomography (PET) studies of extrastriatal D2 dopamine receptors. The purpose of this PET study was to examine the effect of amphetamine on [11C]FLB 457 binding in extrastriatal regions. Each of three cynomolgus monkeys was examined at baseline conditions, 15 min and 3 h after I.V. injection of amphetamine (2 mg/kg). The effect of amphetamine was calculated from the ratio of specific [C-11]FLB 457 binding to the binding in the cerebellum, a region which was used as reference for free and nonspecific bindingin the brain. The changes of the ratio in the striatum, the thalamus, and the neocortex were between -1.2% and -15.5% at 15 min and -2.1% and -16.3% at 3 h, respectively, after amphetamine administration. The reductions of the binding ratios in the extrastriatal regions are similar to those reported for [C-11]raclopride binding in the striatum. These data in a limited series of monkeys suggest that [C-11]FLB 457 binding to D2 dopamine receptors in extrastriatal regions is sensitive to changes in the concentration of endogenous dopamine. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:51:51