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Titolo:
In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism
Autore:
Doudet, DJ; Holden, JE; Jivan, S; McGeer, E; Wyatt, RJ;
Indirizzi:
Univ British Columbia, Dept Med, Div Neurol, Vancouver, BC V6T 2B5, CanadaUniv British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada Univ British Columbia, TRIUMF, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada Univ Wisconsin, Dept Med Phys, Madison, WI USA Univ Wisconsin Madison WI USA Wisconsin, Dept Med Phys, Madison, WI USA NIMH, Neuropsychiat Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 ropsychiat Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 38, anno: 2000,
pagine: 105 - 113
SICI:
0887-4476(200011)38:2<105:IVPSOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; C-11 RACLOPRIDE; RAT-BRAIN; REVEAL DOPAMINE-D2; SYNAPTIC DOPAMINE; SUBSTANTIA-NIGRA; 6-OHDA LESIONS; D-2 RECEPTORS; ANIMAL-MODELS;
Keywords:
raclopride; dopamine D2 receptors; long-term MPTP-induced parkinsonism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Doudet, DJ Univ British Columbia, Dept Med, Div Neurol, Rm M36,Purdy Pavil,2221 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada Univ British Columbia RmM36,Purdy Pavil,2221 Wesbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
D.J. Doudet et al., "In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism", SYNAPSE, 38(2), 2000, pp. 105-113

Abstract

Studies of dopamine (DA) receptor binding in early parkinsonian patients, or in models of Parkinson's disease, have revealed a supersensitivity of the DB-like receptor subtype as compared to age-matched controls. The lack ofupregulation in advanced patients is often attributed to the effects of prolonged antiparkinsonian therapy, but the impact of therapy vs. intrinsic mechanisms in untreated patients or animals with long-term lesions of the DAnigrostriatal pathway has been difficult to address. We studied, in vivo, by PET using the DA D2 receptor ligand raclopride, the status of the DA receptors in normal rhesus monkeys and those with acute (3 months) or long-term (10 years) MPTP-induced nigrostriatal lesions. Compared to age-matched controls, there was no change in raclopride binding in MPTP-treated animals without parkinsonian symptoms. There was a significant increase in raclopride binding in the putamen (but not caudate nucleus) of all the animals displaying rigidity, hypo- and bradykinesia. This increase was greater in the animals with acute lesions (32%) than with established, long-term lesions (18%). There was no correlation between the postmortem striatal DA concentrations and in vivo raclopride binding but there was a correlation between PET raclopride binding and [H-3]radopride binding in vitro. Complex changes in D2 receptor binding occur in various stages of parkinsonism. Antiparkinsonian therapy is unlikely to be solely responsible for the lack of upregulation found in advanced parkinsonian patients but may be a contributing factor. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 21/09/20 alle ore 03:32:57