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Titolo:
Enalapril and prednisone in children with nephrotic-range proteinuria
Autore:
Delucchi, A; Cano, F; Rodriguez, E; Wolff, E; Gonzalez, X; Cumsille, MA;
Indirizzi:
Univ Chile, Hosp Luis Calvo Mackennna, Div Pediat Nephrol, Santiago, ChileUniv Chile Santiago Chile ackennna, Div Pediat Nephrol, Santiago, Chile Univ Chile, Hosp Luis Calvo Mackennna, Biochem Lab, Santiago, Chile Univ Chile Santiago Chile Calvo Mackennna, Biochem Lab, Santiago, Chile Univ Chile, Hosp Luis Calvo Mackennna, Dept Biostat, Santiago, Chile Univ Chile Santiago Chile alvo Mackennna, Dept Biostat, Santiago, Chile
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 12, volume: 14, anno: 2000,
pagine: 1088 - 1091
SICI:
0931-041X(200010)14:12<1088:EAPICW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITORS; GLOMERULAR INJURY; RENAL-DISEASE; HYPERTENSION; RAT; PERMSELECTIVITY; KIDNEY;
Keywords:
enalapril; nephrotic-range proteinuria; electrophoretic urinary pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Delucchi, A Augusto Ovalle 1330-901, Santiago, Chile Augusto Ovalle 1330-901 Santiago Chile 901, Santiago, Chile
Citazione:
A. Delucchi et al., "Enalapril and prednisone in children with nephrotic-range proteinuria", PED NEPHROL, 14(12), 2000, pp. 1088-1091

Abstract

The effect of enalapril and low prednisone doses on the urinary protein electrophoretic pattern was studied in 13 pediatric patients with glomerular diseases and steroid-resistant nephrotic syndrome. Enalapril was administred at doses of 0.2-0.6 mg/kg per day for 24-84 months, and prednisone was introduced 2 months later in II patients at doses of 30 mg/m(2) on alternate days. The urine protein electrophoretic pattern showed a reduction of 80% and 70% in the total protein and albumin, respectively, after enalapril. Total urinary protein decreased from 5.46 to 1.1 g/m(2) per day (P<0.001). A marked change from a pattern of non-selective urinary protein loss to an albumin-selective proteinuria was observed. Mean total plasma proteins increased from 4.7 to 5.43 g/dl (P<0.001). Four patients became foe of proteinuria24 months after enalapril was started, but only 2 remained free of proteinuria at 48 months of follow-up. The other 11 patients had persistent albuminuria of between 0.5 and 2.6 g/m(2) per day with a selective urinary electrophoretic pattern. No additional decrease was observed after steroids were introduced. A clinical improvement in edema was observed in all children, Three patients developed transient acute renal failure, during the course ofan infectious disease; 2 developed peritonitis and I pneumopathy. In thesepatients withdrawal of enalapril was necessary until a complete recovery or renal function was observed. Four patients were hypertensive on admission, achieving normal blood pressure 1 month after enalapril was started. No episodes of systemic arterial hypotension were seen. Creatinine clearance and serum potassium showed no statistically significant change.

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Documento generato il 28/09/20 alle ore 15:29:58