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Titolo:
Progression from allergic sensitization to asthma
Autore:
Warner, JO; Pohunek, P; Marguet, C; Clough, JB; Roche, WR;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England
Titolo Testata:
PEDIATRIC ALLERGY AND IMMUNOLOGY
, volume: 11, anno: 2000, supplemento:, 13
pagine: 12 - 14
SICI:
0905-6157(2000)11:<12:PFASTA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DER-P-I; CHILDREN; INFANTS;
Keywords:
asthma; airway inflammation; eosinophils; neutrophils; allergens; virus infections;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Warner, JO Univ Southampton, Southampton Gen Hosp, Level G803,Ctr Block,Tremona Rd, Southampton SO16 6YD, Hants, England Univ Southampton Level G803,Ctr Block,Tremona Rd Southampton Hants England SO16 6YD
Citazione:
J.O. Warner et al., "Progression from allergic sensitization to asthma", PEDIAT A IM, 11, 2000, pp. 12-14

Abstract

Asthma is one of the atopic diseases strongly associated with allergy. High aeroallergen exposure in the immediate postnatal period has been associated with higher risk of sensitization and chronic asthma. It is proposed that Following in utero allergen sensitization, postnatal high dose allergen exposure localizes inflammation to the airways. In association with adjuvantizing effects of some virus infections, eosinophils and neutrophils are recruited which contribute to epithelial damage and the initiation of the remodelling process. Eventually, the latter processes lead to sufficient airwaynarrowing to manifest as the first symptoms of asthma. Thus, the immunopathology of asthma is fully established by the time of first symptoms and future strategies will need to identify those at risk of developing the disease before irreversible changes in the airways are established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 12:30:12