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Titolo:
Role of fibrinogen covalently associated with cell membrane in blood-bornelung tumor colony formation of murine mammary carcinoma cells
Autore:
Lee, SY; Park, LO; Suk, SH;
Indirizzi:
Catholic Univ Korea, Coll Med, Chem Sect, Dept Nat Sci,Seucho Ku, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Won Kwang Univ Korea, Kunpo Med Ctr, Dept Neurol, Kunpo City, South Korea Won Kwang Univ Korea Kunpo City South Korea ol, Kunpo City, South Korea
Titolo Testata:
ONCOLOGY
fascicolo: 3, volume: 59, anno: 2000,
pagine: 238 - 244
SICI:
0030-2414(2000)59:3<238:ROFCAW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICOAGULANT DRUGS; SURGICAL STRESS; MELANOMA-CELLS; METASTASIS; HYPERTHERMIA; PROTEIN; QUANTITATION; PURIFICATION; PROTECTION; AFFINITY;
Keywords:
metastasis; transglutaminase K; fibrinogen; fibrin, cross-linked; tumor emboli formation; lung tumor colony formation; lymphokine-activated killer cell, cytotoxic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SY Catholic Univ Korea, Coll Med, Chem Sect, Dept Nat Sci,Seucho Ku, 505 Banpo Dong, Seoul 137701, South Korea Catholic Univ Korea 505 Banpo Dong Seoul South Korea 137701 Korea
Citazione:
S.Y. Lee et al., "Role of fibrinogen covalently associated with cell membrane in blood-bornelung tumor colony formation of murine mammary carcinoma cells", ONCOL-BASEL, 59(3), 2000, pp. 238-244

Abstract

The role of fibrinogen covalently associated with cell membrane in blood-borne lung tumor colony formation of murine mammary carcinoma cells in mice was studied. When mice were treated with prednisolone, their plasma fibrinogen levels profoundly increased. Hyperfibrinogenemia, induced by prednisolone treatment or plasma fibrinogen infusion of syngeneic mice, accelerated the coagulation time and significantly increased the number of lung tumor colonies of SCK tumor cells. Hypofibrinogenemia, induced by rabbit antisyngenic mouse fibrinogen immunoglobulin G or heparin infusion, markedly delayed coagulation time and prominently reduced the numbers of blood-borne lung tumor colonies of the tumor cells. SCK mammary carcinoma cells form a coatingof fibrinogen on their surfaces in a medium containing fibrinogen, This coating is crosslinked in a manner characteristic of catalysis by tumor cell membrane-bound transglutaminase K. The fibrinogen coating on the surface ofthese tumor cells functions to protect against autologous lymphokine-activated killer cells. These results provide information on the impact of fibrin stability on blood-borne lung tumor colony formation of SCK mammary carcinoma cells, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:38:11