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Titolo:
The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men
Autore:
Ljung, T; Holm, G; Friberg, P; Andersson, B; Bengtsson, BA; Svensson, J; Dallman, M; McEwen, B; Bjorntorp, P;
Indirizzi:
Sahlgrens Univ Hosp, Dept Heart & Lung Dis, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Med, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 crinol Lab, New York, NY 10021 USA
Titolo Testata:
OBESITY RESEARCH
fascicolo: 7, volume: 8, anno: 2000,
pagine: 487 - 495
SICI:
1071-7323(200010)8:7<487:TAOTHA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; GROWTH-FACTOR-I; CORTISOL SECRETION; INSULIN-RESISTANCE; ABDOMINAL OBESITY; BLOOD-PRESSURE; PHYSIOLOGICAL-ASPECTS; STRESS; WOMEN; HYPERTENSION;
Keywords:
waist/hip ratio; hypothalamic-pituitary-adrenal axis; ACTH; cortisol; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ljung, T Sahlgrens Univ Hosp, Dept Heart & Lung Dis, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 thenburg, Sweden
Citazione:
T. Ljung et al., "The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men", OBES RES, 8(7), 2000, pp. 487-495

Abstract

Objective: To investigate possible differences, between generally and abdominally obese men, in activity and regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Research Methods and Procedures: Fifty non-diabetic, middle-aged men were selected to obtain two groups with similar body mass index (BMI) but different waist/hip circumference ratio (WHR). Measurements were performed of theactivity of the HPA axis and the sympathetic nervous system, as well as metabolic and endocrine variables. Results: Men with a high WHR, in comparisons with men with a low WHR, had higher insulin, glucose, and triglyceride values in the basal state and higher glucose and insulin after an oral glucose tolerance test. Men with highWHR had elevated diurnal adrenocorticotropic hormone (ACTH) values but similar cortisol values, except lower cortisol values in the morning. Diurnal growth hormone concentrations showed reduced peak size. Stimulation of the HPA axis with corticotropin-releasing hormone (CRH) and laboratory stress showed no difference in ACTH values between groups, but cortisol values werelower in-men with high WHR. In comparison with men with a low WHR, men with a high WHR had elevated pulse pressure and heart rate in the basal state and after challenges by CRH and laboratory stress. They also had increased urinary excretion of catecholamine metabolites. Discussion: These results suggest a mild dysregulation of the HPA axis, occurring with elevated WHR independent of the BMI. The results also indicatea central activation of the sympathetic nervous system, such as in the early phases of hypertension, correlating with insulin resistance.

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Documento generato il 05/07/20 alle ore 22:34:23