Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Skin sympathetic neuroeffector response is attenuated dose-dependently by systemic prostaglandin E1 injection in humans
Autore:
Iwase, S; Yamamoto, K; Miwa, C; Kamiya, A; Niimi, Y; Fu, Q; Mano, T;
Indirizzi:
Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan Nagoya Daiichi Red Cross Hosp, Dept Vasc Surg, Nagoya, Aichi, Japan NagoyaDaiichi Red Cross Hosp Nagoya Aichi Japan g, Nagoya, Aichi, Japan Nagoya Univ, Sch Hlth Sci, Dept Rehabil, Nagoya, Aichi 4618673, Japan Nagoya Univ Nagoya Aichi Japan 4618673 abil, Nagoya, Aichi 4618673, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 292, anno: 2000,
pagine: 191 - 194
SICI:
0304-3940(20001013)292:3<191:SSNRIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; SUDOMOTOR; NERVES;
Keywords:
microneurography; skin sympathetic nerve activity; vasoconstrictor; laser Doppler flowmetry; alprostadil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Iwase, S Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan Nagoya Univ Furo Cho Nagoya Aichi Japan 4648601 hi 4648601, Japan
Citazione:
S. Iwase et al., "Skin sympathetic neuroeffector response is attenuated dose-dependently by systemic prostaglandin E1 injection in humans", NEUROSCI L, 292(3), 2000, pp. 191-194

Abstract

To clarify the effects of prostaglandin El (PGE1) on the vasoconstrictive responses, we compared the correlation between the amplitude of integrated skin sympathetic nerve activity (SSNA) and per cent reduction in skin bloodflow (SBF) before and after the infusion of lipo PGE1 and placebo (bolus one-shot infusion, single blind study), and constant rate infusion of PGE1 (10 and 50 ng kg(-1) min(-1) by infusion pump, dose-dependency study) in tenhealthy men. SSNA was recorded microneurographically from the median nervesimultaneously with SBF by laser Doppler flowmetry at the index fingertip. The measurement was conducted 30 min after injection of lipo PGE1 or placebo, and during the drip infusion of 10 and 50 ng kg(-1) min(-1) of PGE1 with maneuvers to enhance SSNA. The resting and activated skin blood flow werenot significantly different between 10 ng lipo PGE1 and placebo administration, and between baseline and 10, 50 ng kg(-1) min(-1) of PGE1 injection. The vascular response, defined as the slope of regression line between logarithm of amplitude of integrated SSNA bursts and the reduction in SBF, was significantly suppressed by injection of lipo PGE1 as compared with that byplacebo. It was also decreased dose-dependently by the constant rate infusion of PGE1 (10 and 50 ng kg(-1) min(-1)). We concluded that the intravenous injection of PGE1 attenuates vasoconstrictive responses to SSNA, and analysis of the relations between SSNA and vasoconstrictive response, i.e. the neuroeffector response, is suggested to be an important tool to assess the drug effect. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:58:27