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Titolo:
Serotonergic dorsal raphe neurons cease firing by disfacilitation during paradoxical sleep
Autore:
Sakai, K; Crochet, S;
Indirizzi:
Univ Lyon 1, Dept Expt Med, INSERM, U480, F-69373 Lyon 08, France Univ Lyon 1 Lyon France 08 pt Med, INSERM, U480, F-69373 Lyon 08, France
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 11, anno: 2000,
pagine: 3237 - 3241
SICI:
0959-4965(20000928)11:14<3237:SDRNCF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING CATS; SYNAPTIC POTENTIALS; UNIT-ACTIVITY; BRAIN-STEM; NUCLEUS; INVITRO; SYSTEM; SUPPRESSION; ANTAGONISTS; BICUCULLINE;
Keywords:
cat; disfacilitation; dorsal raphe unit activity; GABA; histamine; microdialysis; paradoxical sleep; phenylephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, K Univ Lyon 1, Dept Expt Med, INSERM, U480, 8 Ave Rockefeller, F-69373 Lyon 08, France Univ Lyon 1 8 Ave Rockefeller Lyon France 08 373 Lyon 08, France
Citazione:
K. Sakai e S. Crochet, "Serotonergic dorsal raphe neurons cease firing by disfacilitation during paradoxical sleep", NEUROREPORT, 11(14), 2000, pp. 3237-3241

Abstract

Using in vivo extracellular unit recordings combined with microdialysis infusion in the cat, we found that the cessation of discharge of presumed serotonergic dorsal raphe neurons during paradoxical sleep (PS) was completelyblocked by either histamine or phenylephrine, an alpha(1) adrenoceptor agonist, but not by bicuculline, a GABA receptor antagonist. In addition, application of mepyramine, a specific H-1 histamine receptor antagonist, or prazosin, a specific alpha(1) adrenoceptor antagonist, suppressed the spontaneous discharge of raphe neurons during both quiet waking and sleep. The present data suggest that this cessation of dorsal raphe unit activity is caused by the mechanism of disfacilitation resulting from the cessation of discharge of norepinephrine- or histamine-containing neurons during PS. NeuroReport 11:3237-3241 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:17:25