Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic morphine treatment inhibits oxytocin synthesis in rats
Autore:
You, ZD; Li, JH; Song, CY; Wang, CH; Lu, CL;
Indirizzi:
Second Mil Med Univ, Dept Neurobiol, Shanghai 200433, Peoples R China Second Mil Med Univ Shanghai Peoples R China 200433 433, Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 11, anno: 2000,
pagine: 3113 - 3116
SICI:
0959-4965(20000928)11:14<3113:CMTIOS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRAOPTIC NUCLEUS; ANESTHETIZED RATS; NEUROHYPOPHYSEAL PEPTIDES; GUINEA-PIG; TOLERANCE; NEURONS; DEPENDENCE; RELEASE; BRAIN; HYPOTHALAMUS;
Keywords:
in situ hybridization; micropunch; morphine dependence; naloxone; oxytocin; radioimmunoassay; rats; supraoptic nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: You, ZD Second Mil Med Univ, Dept Neurobiol, 800 Xiangyin Rd, Shanghai 200433, Peoples R China Second Mil Med Univ 800 Xiangyin Rd Shanghai Peoples R China 200433
Citazione:
Z.D. You et al., "Chronic morphine treatment inhibits oxytocin synthesis in rats", NEUROREPORT, 11(14), 2000, pp. 3113-3116

Abstract

The changes of oxytocin content and mRNA expression in some nuclei were investigated in morphine-dependent rats using radioimmunoassay (RIA) and in situ hybridization (ISH). After chronic administration of morphine, the oxytocin content in supraoptic nucleus (SON) and nucleus accumbens (NAc) decreased, and increased in the ventral tegment area (VTA) and locus coeruleus (LC), but did not change in other nuclei including the paraventricular nucleus (PVN), lateral septum (SEPTUM), raphe magnus nucleus (NRM) and periaquaductal gray (PAG). In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC. ISH first showed that chronic morphine treatment inhibited the oxytocin synthesis in SON but not in PVN. The present study demonstrates that chronic morphine treatment alters the brain oxytocin system, suggesting that oxytocin might contribute to the behavioral and neuroendocrine responses to morphine. NeuroReport 11:3113-3116 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:53:47