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Titolo:
WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801
Autore:
Wedzony, K; Mackowiak, M; Zajaczkowski, W; Fijal, K; Chocyk, A; Czyrak, A;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow 12, Poland Polish Acad Sci Krakow Poland 12 t Pharmacol, PL-31343 Krakow 12, Poland
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 23, anno: 2000,
pagine: 547 - 559
SICI:
0893-133X(200011)23:5<547:W1AAO5>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; RAT PREFRONTAL CORTEX; FREELY-MOVING RATS; PREPULSE INHIBITION; WORKING-MEMORY; DOPAMINE RELEASE; NUCLEUS-ACCUMBENS; COMPETITIVE NMDA; ACOUSTIC STARTLE; (5-HT)(1A) RECEPTORS;
Keywords:
delayed alternation; serotonin 5-HT1A receptors; locomotor activity; MK-801; prepulse inhibition; schizophrenia; startle reflex; WAY 100135; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Wedzony, K Polish Acad Sci, Inst Pharmacol, Smetna St, PL-31343 Krakow 12,Poland Polish Acad Sci Smetna St Krakow Poland 12 3 Krakow 12, Poland
Citazione:
K. Wedzony et al., "WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801", NEUROPSYCH, 23(5), 2000, pp. 547-559

Abstract

In the present study, we investigated whether the antagonist of 5-HT1A receptors, WAY 100135, was capable of modifying the psychostimulant and psychotomimetic effects of MK-801, a non-competitive antagonist of NMDA receptors. If was found that: 1) WAY 100135 (10 and 20 mg/kg, but not 1.25, 2.5, and5 mg/kg) transiently, in a dose dependent manner, attenuated the locomotorstimulant effects of MK-801 (0.4 mg/kg). Given alone, WAY 100135 had no effect on the locomotor activity of rats; 2) WAY 100135 (1.25 and 2.5 mg/kg, but not 10 or 20 mg/kg), attenuated or abolished the disruptive effects of MK-801 on the sensorimotor gating measured in a prepulse-induced inhibitionof the acoustic startle response paradigm. WAY 100135 in all tested doses had no effect on the sensorimotor gating or amplitude of the acoustic startle response; 3) WAY 100135 (1.25, 2.5 mg/kg, but not 5 mg/kg) attenuated the detrimental effects of MK-801 on working memory and selective attention, measured in a delayed alternation task. Again, given alone, WAY 100135 did not influence the behavior of rats in that experimental paradigm; and 4) MK-801 (0.4 mg/kg) had no effect on the 5-HT1A receptor mRNA level in rat hippocampus, measured 2 and 24 hours after MK-801 administration. These data indicate that 5-HT1A recptors might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. In addition, 5-HT1A serotonin receptor antagonists and partial agonists may have potential antipsychotic properties. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

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Documento generato il 27/01/20 alle ore 16:53:30