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Titolo:
"Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits
Autore:
Martinez, ZA; Oostwegel, J; Geyer, MA; Ellison, GD; Swerdlow, NR;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Utrecht, Fac Pharm, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands recht, Fac Pharm, Utrecht, Netherlands
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 23, anno: 2000,
pagine: 517 - 527
SICI:
0893-133X(200011)23:5<517:"A"EOS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFORMATION-PROCESSING DEFICITS; PREPULSE INHIBITION DEFICITS; SCHIZOPHRENIC-PATIENTS; ACOUSTIC STARTLE; ANIMAL-MODEL; DOPAMINERGIC SYSTEM; NUCLEUS-ACCUMBENS; RATS; CLOZAPINE; HABITUATION;
Keywords:
apomorphine; haloperidol; phencyclidine; prepulse inhibition; schizophrenia; sensorimotor; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 lla, CA 92093 USA
Citazione:
Z.A. Martinez et al., ""Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits", NEUROPSYCH, 23(5), 2000, pp. 517-527

Abstract

Both dopamine (DA) agonists and NMDA antagonists produce prepulse inhibition (PPI) deficits in rats that model PPI deficits in schizophrenia patients. While DA agonist effects on PPT are reversed by acute treatment with either "typical" high-potency D2 DA antagonists or "atypical" antipsychotics, PPI deficits produced by phencyclidine (PCP) are preferentially reversed by acute treatment with "atypical" antipsychotics. Acute effects of antipsychotics may not accurately model the more clinically relevant effects of thesedrugs that emerge after several weeks of continuous treatment. In the present study, sustained treatment with haloperidol via subcutaneous minipumps blocked the PPI-disruptive effects of apomorphine and attenuated the PCP-induced disruption of PPI. Restoration of PPI in apomorphine-treated rats wasevident within the first week of sustained haloperidol administration. A partial reversal of PCP effects on Pm did not develop until the second week of sustained haloperidol treatment,followed a fluctuating course, but remained significant into the seventh week of sustained haloperidol administration. The delayed emergence of anti-PCP effects of haloperidol suggests that the brain substrates responsible for the DAergic and NMDA regulation of PPIare differentially sensitive to acute and chronic effects of antipsychotics. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:15:39