Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Heparins and blood polymorphonuclear stimulation in haemodialysis: an expansion of the biocompatibility concept
Autore:
Leitienne, P; Fouque, D; Rigal, D; Adeleine, P; Trzeciak, MC; Laville, M;
Indirizzi:
Hop P Wertheimer, Ctr Hemodialyse, F-69003 Lyon, France Hop P Wertheimer Lyon France F-69003 r Hemodialyse, F-69003 Lyon, France Hop Edouard Herriot, Dept Nephrol, Lyon, France Hop Edouard Herriot LyonFrance ard Herriot, Dept Nephrol, Lyon, France Etab Transfus Sanguine, Lyon, France Etab Transfus Sanguine Lyon FranceEtab Transfus Sanguine, Lyon, France Hop Lyon, Lab Informat Med, Lyon, France Hop Lyon Lyon FranceHop Lyon, Lab Informat Med, Lyon, France Hop Edouard Herriot, Hemostase Lab, Lyon, France Hop Edouard Herriot Lyon France rd Herriot, Hemostase Lab, Lyon, France
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 10, volume: 15, anno: 2000,
pagine: 1631 - 1637
SICI:
0931-0509(200010)15:10<1631:HABPSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT HEPARIN; COMPLEMENT ACTIVATION; NEUTROPHIL DEGRANULATION; CITRATE ANTICOAGULATION; CHRONIC-HEMODIALYSIS; DIALYSIS MEMBRANES; CELLULOSE-ACETATE; ELASTASE; AGGREGATION; INHIBITION;
Keywords:
biocompatibility; elastase; haemodialysis; heparins; lactoferrin; polymorphonuclear cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Leitienne, P Hop P Wertheimer, Ctr Hemodialyse, 52 Blvd Pinel, F-69003 Lyon, France Hop P Wertheimer 52 Blvd Pinel Lyon France F-69003 n, France
Citazione:
P. Leitienne et al., "Heparins and blood polymorphonuclear stimulation in haemodialysis: an expansion of the biocompatibility concept", NEPH DIAL T, 15(10), 2000, pp. 1631-1637

Abstract

Background. At the concentrations used in haemodialysis and in a dose-dependent way, unfractionated heparin (UFH) and, to a lesser degree, a low-molecular-weight heparin (LMWH) stimulate polymorphonuclear cells (PMN) in vitro, and could act in synergy with the stimulatory effect of dialysis membranes in vivo. To examine this hypothesis, we studied the effects of differentheparin types and regimens on blood PMNs during haemodialysis sessions. Methods. Ten haemodialysed patients were studied during regular dialysis sessions on a cellulose triacetate membrane (CT 110 G; 1.10 m(2); Baxter), with four different random heparin protocols: one high-UFH regimen (HHR) at 90 IU/kg body-weight (b.w.) and one low-UFH regimen (LHR) at 50 IU/kg b.w.,and with a LMWH (nadroparin calcium) at 85 (HHR) or 45 (LHR) IU/kg b.w. Blood granulocytes, platelet counts, and plasma granulocyte degranulation products (elastase, lactoferrin) were measured serially during 4 h dialysis sessions. Results. After 10 min, the reduction in PMNs with UFH: was 29.5% for HHR (P < 0.01) and 28.5% for LHR (P < 0.01), and only 16.8 and 18.6% with LMWH (NS), significantly higher for HHR with UFH than with LMWH (P < 0.01). At 60min, the elastase increase with HHR was greater, 61% with UFH (P < 0.01) and 37.8% with LMWH (P < 0.01), significantly higher than LHR for UFH (P < 0.05) or LMWH (P < 0.05). The overall decrease in platelets (with LMWH P < 0.01) and the overall increase in lactoferrin (P < 0.001) were not differentbetween heparinization procedures. Conclusion. Under a conventional heparin regimen, the PMN variation duringthe course of the dialysis session suggests a more biocompatible effect ofLMWH over UFH. In addition, the variation of elastase favours the lower dose, whatever the type of heparin. Heparin type and dose should therefore beconsidered in studies addressing biocompatibility in haemodialysis: a low dose of LMWH may be viewed as a better biocompatible treatment with regard to leukocyte stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:19:27