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Titolo:
Intestinal protein loss in patients with haemorrhagic fever with renal syndrome
Autore:
Kim, YO; Yang, CW; Yoon, SA; Song, HC; Kim, YS; Kim, SY; Choi, EJ; Chang, YS; Bang, BK;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea Catholic Univ Korea Seoul South Korea Internal Med, Seoul, South Korea
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 10, volume: 15, anno: 2000,
pagine: 1588 - 1592
SICI:
0931-0509(200010)15:10<1588:IPLIPW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOSING ENTEROPATHY; HEMORRHAGIC-FEVER; HANTAVIRUS INFECTION; ALBUMIN SCINTIGRAPHY; DISEASE; ALPHA-1-ANTITRYPSIN; CLEARANCE; CHILDREN;
Keywords:
haemorrhagic fever; renal syndrome; hypoalbuminaemia; intestinal tract;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bang, BK Catholic Univ, Coll Med, Kangnam St Marys Hosp, Dept Internal Med, 505 Banpo Dong, Seoul 137701, South Korea Catholic Univ 505 Banpo Dong Seoul South Korea 137701 outh Korea
Citazione:
Y.O. Kim et al., "Intestinal protein loss in patients with haemorrhagic fever with renal syndrome", NEPH DIAL T, 15(10), 2000, pp. 1588-1592

Abstract

Background. In haemorrhagic fever with renal drome (HFRS) vascular dysfunction has been observed in various organs, but the involvement of the intestine has not yet been reported. This study was performed to evaluate the association of intestinal protein loss in this disease with other clinical parameters reflecting vascular permeability or disease severityMethods. Twenty patients with HFRS were included in this study. Intestinalprotein loss was measured by Tc-99m-human serum albumin (Tc-99m-HSA) scintigraphy in the acute stage, and quantitative analysis of protein loss was measured by the faecal clearance of alpha 1-antitrypsin (C-AT) in the acute and the recovery stages. C-AT was then compared with clinical parameters reflecting disease activity and vascular permeability. Results. Tc-99m-HSA scintigraphy was positive in 13 (65%) patients, and C-AT in the acute stage was significantly increased as compared with C-AT in the recovery stage (40,5 +/- 24.1 vs 9.2 +/- 4.2 ml/day, P < 0.001). C-AT was associated with serum albumin levers, frequency of hypotensive episodes,severity of acute renal failure, and degree of thrombocytopenia. Conclusions. Our data suggest that the increased vascular permeability of HFRS is associated with the increased intestinal loss of plasma proteins, which might represent one of the parameters of disease severity in HFRS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:45:25