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Titolo:
CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha(+) dendritic cells
Autore:
Aliberti, J; Sousa, CRE; Schito, M; Hieny, S; Wells, T; Huffnagle, GB; Sher, A;
Indirizzi:
NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA Ares Serono Pharmaceut Res Inst SA, Geneva, Switzerland Ares Serono Pharmaceut Res Inst SA Geneva Switzerland neva, Switzerland Imperial Canc Res Fund, Immunobiol Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Univ Michigan, Med Ctr, Dept Pulm Med, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA Med Ctr, Dept Pulm Med, Ann Arbor, MI USA Univ Michigan, Med Ctr, Dept Immunol Microbiol, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA Dept Immunol Microbiol, Ann Arbor, MI USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 1, volume: 1, anno: 2000,
pagine: 83 - 87
SICI:
1529-2908(200007)1:1<83:CPASFM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXOPLASMA-GONDII; CHEMOKINE RECEPTOR-5; MACROPHAGE FUNCTION; ACUTE INFECTION; TROPIC HIV-1; IFN-GAMMA; IMMUNITY; INTERLEUKIN-12; MICE; RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Aliberti, J NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA NIAID 9000 Rockville Pike Bethesda MD USA 20892, MD 20892 USA
Citazione:
J. Aliberti et al., "CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha(+) dendritic cells", NAT IMMUNOL, 1(1), 2000, pp. 83-87

Abstract

The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha(+) subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasiteToxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:28:11