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Titolo:
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
Autore:
Pandey, A; Ozaki, K; Baumann, H; Levin, SD; Puel, A; Farr, AG; Ziegler, SF; Leonard, WJ; Lodish, HF;
Indirizzi:
NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA20892 Lab Mol Immunol, NIH, Bethesda, MD 20892 USA Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Pathol, Boston, MA 02115 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA Roswell Pk Canc Inst Buffalo NY USA 14263 lar Biol, Buffalo, NY 14263 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Biol Struct, Seattle, WA 98195 USA Virginia Mason Res Ctr, Seattle, WA 98101 USA Virginia Mason Res Ctr Seattle WA USA 98101 es Ctr, Seattle, WA 98101 USA MIT, Dept Biol, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142MIT, Dept Biol, Cambridge, MA 02142 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 1, volume: 1, anno: 2000,
pagine: 59 - 64
SICI:
1529-2908(200007)1:1<59:COARSR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON GAMMA-CHAIN; JAK-3 JANUS KINASE; IGM(+) B-CELLS; IL-2 RECEPTOR; BETA-CHAIN; INTERLEUKIN-7 RECEPTOR; FUNCTIONAL COMPONENT; LYMPHOID DEVELOPMENT; CYTOPLASMIC DOMAINS; CYTOKINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Leonard, WJ NHLBI, Lab Mol Immunol, NIH, Bldg 10, Bethesda, MD 20892 USA NHLBI Bldg 10 Bethesda MD USA 20892 10, Bethesda, MD 20892 USA
Citazione:
A. Pandey et al., "Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin", NAT IMMUNOL, 1(1), 2000, pp. 59-64

Abstract

Signaling by type 1 cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that is most closely related to the common cytokine receptor gamma chain (gamma(c)). Binding and crosslinking experiments demonstrate that this protein is the receptor for a recently described interleukin 7 (IL-7)-like factor, thymic stromal lymphopoietin (TSLP). Binding of TSLP to the thymic stromal lymphopoietin receptor (TSLPR) is increased markedly in the presence of the IL-7 receptor alpha chain (IL-7R alpha). IL-7R alpha-expressing but not parental 32D cells proliferate inthe presence of exogenous TSLP, Moreover, a combination of IL-7R alpha andTSLPR is required for TSLP-dependent activation of a STAT5-dependent reporter construct. Thus it is shown that IL-7R alpha is a component of both theIL-7 and TSLP receptors, which helps to explain why deletion of the gene that encodes IL-7R alpha affects the lymphoid system more severely than deletion of the gene encoding IL-7 does. Cloning of TSLPR should facilitate an understanding of TSLP function and its signaling mechanism.

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Documento generato il 29/03/20 alle ore 18:20:55