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Titolo:
gamma chain required for naive CD4(+) T cell survival but not for antigen proliferation
Autore:
Lantz, O; Grandjean, I; Matzinger, P; Di Santo, JP;
Indirizzi:
Inst Pasteur, Unite Cytokines & Dev Lymphoide, Paris, France Inst PasteurParis France nite Cytokines & Dev Lymphoide, Paris, France NIAID, Ghost Lab, LCMI, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA20892 Ghost Lab, LCMI, NIH, Bethesda, MD 20892 USA Univ Paris 11, Le Kremlin Bicetre, France Univ Paris 11 Le Kremlin Bicetre France 11, Le Kremlin Bicetre, France Hop Necker Enfants Malad, INSERM, U25, Paris, France Hop Necker Enfants Malad Paris France Malad, INSERM, U25, Paris, France
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 1, volume: 1, anno: 2000,
pagine: 54 - 58
SICI:
1529-2908(200007)1:1<54:GCRFNC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE RECEPTORS; POSITIVE SELECTION; MICE DEFICIENT; IN-VIVO; MEMORY; BCL-2; DIFFERENTIATION; LYMPHOCYTES; VIRGIN; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP Inst Pasteur, Unite Cytokines & Dev Lymphoide, Paris, France Inst Pasteur Paris France s & Dev Lymphoide, Paris, France
Citazione:
O. Lantz et al., "gamma chain required for naive CD4(+) T cell survival but not for antigen proliferation", NAT IMMUNOL, 1(1), 2000, pp. 54-58

Abstract

Lymphoid homeostasis is required to ensure immune responsiveness and to prevent immunodeficiency, As such, the immune system must maintain distinct populations of naive T cells that are able to respond to new antigens as well as memory T cells specific to those antigens it has already encountered,Though both naive and memory T cells reside in and traffic through secondarylymphoid organs, there is growing evidence that the two populations may beregulated differently,We show here that naive T cell survival and memory Tcell survival have different requirements for cytokines (including the interleukins IL-2, IL-4, IL-7, IL-9 and IL-15) that use the common cytokine receptor gamma chain (gamma(c)). Using monoclonal populations of antigen-specific CD4(+) T cells, we found that naive T cells cannot survive without gamma(c), whereas memory T cells show no such requirement. In contrast, neither naive nor gamma(c)-deficient memory T cells were impaired in their ability to proliferate and produce cytokines in response to in vivo antigenic stimulation,These data call into question the physiological role of gamma(c)-dependent cytokines as T cell growth factors and show that naive and memory CD4(+)T cell survival is maintained by distinct mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:06:48