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Titolo:
Costimulatory blockade by the induction of an endogenous xenospecific antibody response
Autore:
Rogers, NJ; Mirenda, V; Jackson, I; Dorling, A; Lechler, RI;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, London W12 0NN,England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 2, volume: 1, anno: 2000,
pagine: 163 - 168
SICI:
1529-2908(200008)1:2<163:CBBTIO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM ACCEPTANCE; T-CELL ACTIVATION; TRANSPLANT REJECTION; CARDIAC ALLOGRAFTS; ISLET; CTLA4IG; XENOTRANSPLANTATION; PREVENTION; REPERTOIRE; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lechler, RI Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Hammersmith Campus,Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
N.J. Rogers et al., "Costimulatory blockade by the induction of an endogenous xenospecific antibody response", NAT IMMUNOL, 1(2), 2000, pp. 163-168

Abstract

Xenogeneic tissues induce vigorous T cell immunity, reflecting the abilityof costimulatory molecules to function across species barriers. We describe a strategy to inhibit costimulation that exploits species differences using the model of porcine pancreatic islet transplantation into mice. Mice were immunized with chimeric peptides that contained a known T cell epitope and selected sequences of the porcine costimulatory molecule CD86. This resulted in anti-peptide antibody responses that recognized intact porcine CD86, blocked costimulation by porcine CD86 but not murine CD86 in vitro, and prolonged the survival of porcine islet grafts in vivo. This strategy of inducing endogenous donor-specific costimulatory blockade has potential clinical applicability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:41:13