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Titolo:
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
Autore:
Ayabe, T; Satchell, DP; Wilson, CL; Parks, WC; Selsted, ME; Ouellette, AJ;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Pathol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pathol, Irvine, CA 92697 USA Univ Calif Irvine, Coll Med, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 l & Mol Genet, Irvine, CA 92697 USA Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 l & Physiol, St Louis, MO 63110 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 2, volume: 1, anno: 2000,
pagine: 113 - 118
SICI:
1529-2908(200008)1:2<113:SOMABI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNATE HOST-DEFENSE; ANTIMICROBIAL PEPTIDE; TRANSGENIC MICE; MICROSCOPIC OBSERVATIONS; HUMAN BETA-DEFENSIN-1; PHOSPHOLIPASE A(2); PHAGOCYTIC-CELLS; GENE-EXPRESSION; WISTAR RATS; ANTIBIOTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ouellette, AJ Univ Calif Irvine, Coll Med, Dept Pathol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Irvine, CA 92697 USA
Citazione:
T. Ayabe et al., "Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria", NAT IMMUNOL, 1(2), 2000, pp. 113-118

Abstract

Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins, account for 70% of the released bactericidal peptide activity. Gram-negative bacteria, Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit cryptdin secretion. Live fungi and protozoa, however, do not stimulate degranulation. Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:59:10