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Titolo:
Localization of E-cadherin in villous, extravillous and vascular trophoblasts during intrauterine, ectopic and molar pregnancy
Autore:
Floridon, C; Nielsen, O; Holund, B; Sunde, L; Westergaard, JG; Thomsen, SG; Teisner, B;
Indirizzi:
Odense Univ Hosp, Dept Obstet & Gynaecol, DK-5000 Odense C, Denmark OdenseUniv Hosp Odense Denmark C & Gynaecol, DK-5000 Odense C, Denmark Odense Univ Hosp, Inst Pathol, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 Pathol, DK-5000 Odense, Denmark Odense Univ Hosp, Dept Immunol & Microbiol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C & Microbiol, DK-5000 Odense C, Denmark Aarhus Univ Hosp, Inst Human Genet, Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark Hosp, Inst Human Genet, Aarhus, Denmark
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 10, volume: 6, anno: 2000,
pagine: 943 - 950
SICI:
1360-9947(200010)6:10<943:LOEIVE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE HYDATIDIFORM MOLE; CELL-ADHESION MOLECULES; ENDOVASCULAR INVASION; METHOTREXATE TREATMENT; HUMAN CYTOTROPHOBLASTS; PATHOLOGICAL RESEARCH; PROLIFERATION; DISEASE; CANCER; IMPLANTATION;
Keywords:
E-cadherin; hydatidiform mole; invasion; placentation; trophoblasts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Floridon, C Odense Univ Hosp, Dept Obstet & Gynaecol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C DK-5000 Odense C, Denmark
Citazione:
C. Floridon et al., "Localization of E-cadherin in villous, extravillous and vascular trophoblasts during intrauterine, ectopic and molar pregnancy", MOL HUM REP, 6(10), 2000, pp. 943-950

Abstract

Previous reports have described down-regulation of E-cadherin in trophoblasts differentiating to an invasive phenotype. This study shows the localization of E-cadherin in a prospective design with stereological sampling of fetal and maternal first, second and third trimester tissue. E-cadherin was observed in villous cytotrophoblasts, and in non-proliferating, intermediate trophoblasts (IT) within cell columns and islands in intrauterine, ectopic and partial molar placentas. Highly proliferating IT with cytological atypia in complete molar placentas were also E-cadherin-positive. E-cadherin was present in trophoblasts throughout the anchoring cell columns. Trophoblasts undergoing epithelial mesenchymal transformation (EMT) detaching from the distal cell columns and deeper located single extravillous interstitial trophoblasts (EVT) showed E-cadherin-negative breaches in the cell membrane. Prior to the late second trimester, the relative number of E-cadherin-positive single EMT and EVT differed from the total number of cytokeratin-positive trophoblasts. Intraluminal, endovascular and perivascular trophoblastsadjacent to the maternal vessels were also E-cadherin-positive but a highly varying pattern was observed at different ages of gestation. Our results indicate a temporary shift in E-cadherin expression in extravillous trophoblasts possessing a migrating and invasive potential. Functional E-cadherin may be restored as trophoblasts aggregate in the decidua and the vessel wall after completion of migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:58:47