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Titolo:
Time-course effects of a single administration of cocaine on receptor binding and subunit mRNAs of GABA(A) receptors
Autore:
Yamaguchi, M; Suzuki, T; Abe, S; Baba, A; Ito, T; Okado, N;
Indirizzi:
Okayama Univ, Fac Educ, Okayama, Japan Okayama Univ Okayama JapanOkayama Univ, Fac Educ, Okayama, Japan Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 chiat, Tsukuba, Ibaraki 305, Japan Inst Basic Med Sci, Dept Anat, Neurobiol Lab, Tsukuba, Ibaraki 3058575, Japan Inst Basic Med Sci Tsukuba Ibaraki Japan 3058575 , Ibaraki 3058575, Japan
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 81, anno: 2000,
pagine: 155 - 163
SICI:
0169-328X(20000930)81:1-2<155:TEOASA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; IN-VIVO MICRODIALYSIS; NUCLEUS-ACCUMBENS; MESSENGER-RNA; RAT-BRAIN; EXTRACELLULAR DOPAMINE; DENTATE GYRUS; BENZODIAZEPINE RECEPTORS; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX;
Keywords:
GABA(A) receptor; cocaine; subunit mRNA; [S-35]TBPS binding; time course;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Okayama Univ, Fac Educ, 2-5-1 Shikata Cho, Okayama, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan o, Okayama, Japan
Citazione:
M. Yamaguchi et al., "Time-course effects of a single administration of cocaine on receptor binding and subunit mRNAs of GABA(A) receptors", MOL BRAIN R, 81(1-2), 2000, pp. 155-163

Abstract

We investigated the time-course effects of a single administration of cocaine (20 mg/kg) on GABA(A) receptor binding labeled by t-[S-35]butylbicyclophophorothionate (TBPS) and on several types of GABA(A) receptor subunit mRNAs in the rat brain by in vitro quantitative receptor autoradiography and in situ hybridization. The levels of alpha 1, beta 2, and beta 3 subunit mRNAs in several brain regions such as the cortex, cerebellum, and striatum were significantly decreased within 1 h, while beta 3 subunit mRNA was increased in the dentate gyrus. All of these changes were transient, occurring within I h after the injection of cocaine. In the cortex and cerebellum, the reduction in oil subunit mRNA was followed by a significant decrease in [35S]TBPS receptor binding, which occurred 4 h after cocaine injection. These findings suggest that acute cocaine administration discretely regulates GABA(A) receptor subunit mRNA levels in several brain regions through a changein transcription or turnover rates of subunit mRNAs, which may be closely related to cocaine-induced behavioral abnormalities. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:34:59